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- W2617239062 abstract "Germline-expressed endogenous small interfering RNAs (endo-siRNAs) transmit multigenerational epigenetic information to ensure fertility in subsequent generations. In Caenorhabditis elegans, nuclear RNAi ensures robust inheritance of endo-siRNAs and deposition of repressive H3K9me3 marks at target loci. How target silencing is maintained in subsequent generations is poorly understood. We discovered that morc-1 is essential for transgenerational fertility and acts as an effector of endo-siRNAs. Unexpectedly, morc-1 is dispensable for siRNA inheritance but is required for target silencing and maintenance of siRNA-dependent chromatin organization. A forward genetic screen identified mutations in met-1, which encodes an H3K36 methyltransferase, as potent suppressors of morc-1(-) and nuclear RNAi mutant phenotypes. Further analysis of nuclear RNAi and morc-1(-) mutants revealed a progressive, met-1-dependent enrichment of H3K36me3, suggesting that robust fertility requires repression of MET-1 activity at nuclear RNAi targets. Without MORC-1 and nuclear RNAi, MET-1-mediated encroachment of euchromatin leads to detrimental decondensation of germline chromatin and germline mortality." @default.
- W2617239062 created "2017-06-05" @default.
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- W2617239062 date "2017-05-01" @default.
- W2617239062 modified "2023-10-15" @default.
- W2617239062 title "MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality" @default.
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- W2617239062 doi "https://doi.org/10.1016/j.devcel.2017.04.023" @default.
- W2617239062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5527976" @default.
- W2617239062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28535375" @default.
- W2617239062 hasPublicationYear "2017" @default.
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