FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617243418> ?p ?o ?g. }

• W2617243418 endingPage "2266" @default.
• W2617243418 startingPage "2258" @default.
• W2617243418 abstract "The SLC8A1 (solute carrier family 8, member 1) gene, encoding Na+ /Ca2+ exchanger, is essential in regulating calcium reabsorption and homeostasis. Calcium homeostasis plays a key role in cell proliferation and apoptosis. We hypothesized that polymorphisms in five calcium-regulating genes (SLC8A1, ATP2B1, CALB1, CALB2, and CABP1) interact with calcium intake in relation to the risk of colorectal neoplasia. A two-phase (discovery and replication) study was conducted within the Tennessee Colorectal Polyp Study, including a total of 1275 cases and 2811 controls. In Phase I, we identified six out of 135 SNPs that significantly interacted with calcium intake in relation to adenoma risk. In Phase II, the calcium intake by rs4952490 (SLC8A1) interaction was replicated (Pinteraction = 0.048). We found an inverse association between calcium intake (1000-2000 mg/day) and colorectal adenomas, particularly for multiple/advanced adenomas, among the G-allele carriers but not among homozygous carriers of the common variant (A) in rs4952490. In the joint analysis of SLC8A1, KCNJ1, and SLC12A1 SNPs, carriers of variant alleles in at least two genes and with calcium intake above the DRI (1000 mg/day) were approximately 30-57% less likely to have adenomas than those whose calcium intake was below the DRI. The association was stronger for multiple/advanced adenomas. No association was found among those who did not carry any variant alleles in these genes when calcium intake was below 2500 mg/day. These findings, if confirmed, may provide a new avenue for the personalized prevention of colorectal adenoma and cancer." @default.
• W2617243418 created "2017-06-05" @default.
• W2617243418 creator A5004289607 @default.
• W2617243418 creator A5005513706 @default.
• W2617243418 creator A5012727097 @default.
• W2617243418 creator A5013254336 @default.
• W2617243418 creator A5027969240 @default.
• W2617243418 creator A5029744335 @default.
• W2617243418 creator A5030538673 @default.
• W2617243418 creator A5032449072 @default.
• W2617243418 creator A5035695257 @default.
• W2617243418 creator A5038373228 @default.
• W2617243418 creator A5039255144 @default.
• W2617243418 creator A5045473616 @default.
• W2617243418 creator A5048159778 @default.
• W2617243418 creator A5052267876 @default.
• W2617243418 creator A5056193431 @default.
• W2617243418 creator A5080728144 @default.
• W2617243418 creator A5087018671 @default.
• W2617243418 date "2017-06-15" @default.
• W2617243418 modified "2023-10-14" @default.
• W2617243418 title "Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two-phase study" @default.
• W2617243418 cites W1968160337 @default.
• W2617243418 cites W2013498384 @default.
• W2617243418 cites W2021935664 @default.
• W2617243418 cites W2023661261 @default.
• W2617243418 cites W2036373340 @default.
• W2617243418 cites W2037632699 @default.
• W2617243418 cites W2051934417 @default.
• W2617243418 cites W2052249826 @default.
• W2617243418 cites W2069465345 @default.
• W2617243418 cites W2070230940 @default.
• W2617243418 cites W2072908173 @default.
• W2617243418 cites W2079063838 @default.
• W2617243418 cites W2089931177 @default.
• W2617243418 cites W2095046262 @default.
• W2617243418 cites W2099191756 @default.
• W2617243418 cites W2103601316 @default.
• W2617243418 cites W2104281323 @default.
• W2617243418 cites W2108995155 @default.
• W2617243418 cites W2115295786 @default.
• W2617243418 cites W2116529135 @default.
• W2617243418 cites W2118913969 @default.
• W2617243418 cites W2120309065 @default.
• W2617243418 cites W2125155338 @default.
• W2617243418 cites W2133470612 @default.
• W2617243418 cites W2134345995 @default.
• W2617243418 cites W2146915571 @default.
• W2617243418 cites W2149086310 @default.
• W2617243418 cites W2153942663 @default.
• W2617243418 cites W2156394393 @default.
• W2617243418 cites W2159438502 @default.
• W2617243418 cites W2159610580 @default.
• W2617243418 cites W2161308794 @default.
• W2617243418 cites W2167233279 @default.
• W2617243418 cites W2319963574 @default.
• W2617243418 cites W2335815721 @default.
• W2617243418 cites W2395085828 @default.
• W2617243418 cites W2426032206 @default.
• W2617243418 cites W78780775 @default.
• W2617243418 doi "https://doi.org/10.1002/mc.22678" @default.
• W2617243418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5609815" @default.
• W2617243418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28544176" @default.
• W2617243418 hasPublicationYear "2017" @default.
• W2617243418 type Work @default.
• W2617243418 sameAs 2617243418 @default.
• W2617243418 citedByCount "8" @default.
• W2617243418 countsByYear W26172434182018 @default.
• W2617243418 countsByYear W26172434182019 @default.
• W2617243418 countsByYear W26172434182020 @default.
• W2617243418 countsByYear W26172434182021 @default.
• W2617243418 countsByYear W26172434182022 @default.
• W2617243418 countsByYear W26172434182023 @default.
• W2617243418 crossrefType "journal-article" @default.
• W2617243418 hasAuthorship W2617243418A5004289607 @default.
• W2617243418 hasAuthorship W2617243418A5005513706 @default.
• W2617243418 hasAuthorship W2617243418A5012727097 @default.
• W2617243418 hasAuthorship W2617243418A5013254336 @default.
• W2617243418 hasAuthorship W2617243418A5027969240 @default.
• W2617243418 hasAuthorship W2617243418A5029744335 @default.
• W2617243418 hasAuthorship W2617243418A5030538673 @default.
• W2617243418 hasAuthorship W2617243418A5032449072 @default.
• W2617243418 hasAuthorship W2617243418A5035695257 @default.
• W2617243418 hasAuthorship W2617243418A5038373228 @default.
• W2617243418 hasAuthorship W2617243418A5039255144 @default.
• W2617243418 hasAuthorship W2617243418A5045473616 @default.
• W2617243418 hasAuthorship W2617243418A5048159778 @default.
• W2617243418 hasAuthorship W2617243418A5052267876 @default.
• W2617243418 hasAuthorship W2617243418A5056193431 @default.
• W2617243418 hasAuthorship W2617243418A5080728144 @default.
• W2617243418 hasAuthorship W2617243418A5087018671 @default.
• W2617243418 hasBestOaLocation W26172434182 @default.
• W2617243418 hasConcept C104317684 @default.
• W2617243418 hasConcept C106208931 @default.
• W2617243418 hasConcept C121608353 @default.
• W2617243418 hasConcept C126322002 @default.
• W2617243418 hasConcept C134018914 @default.
• W2617243418 hasConcept C135763542 @default.

• next