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- W2617255750 abstract "In this study we determined cytotoxicity of sanguirubine (SR),chelirubine (CHR), sanguilutine (SL), chelilutine (CHL) andmacarpine (MA), minor occuring quaternarybenzo[c]phenanthridine alkaloids (QBA), in comparison with thetwo best known QBA sanguinarine (SA) and chelerythrine (CHE).QBA are a small group of isoquinoline alkaloids that aredistributed in a plant species of Papaveraceae, Fumariaceae andRutaceae families. SA and CHE exhibit wide spectrum ofbiological activities, while the information about thebiological effects of minority QBA is rare. Our attention waspointed to study antiproliferative and pro-apoptotic activitiesof QBA and their influence on cytoskeleton. Theantiproliferative activity was assessed by MTT metabolic assay.One normal human (LEP), one hamster (V-79) and three humantumour cell lines (HeLa; HL-60; A-2780) were used as a modelobjects. Our results showed that IC50 values after 72 hourstreatment of alkaloids were comparable with IC50 of routinelyused cytostatics (i.e.: 0,01-1 microgram/ml). HL-60 was themost sensitive cell line while HeLa cells appeared to be themost resistant. For apoptosis detection morphology of nuclei ofalkaloid treated HL-60 cells after DAPI staining was studiedand flow cytometric analysis using Annexin V-FITC and propidiumiodide was applied. All tested alkaloids appeared to beinductors of apoptosis at the concentration 1 microgram/ml.Based on our observations we concluded that alkaloids tested inthis study show strong antiproliferative, proapoptotic effectand effect on cytoskeleton." @default.
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- W2617255750 date "2006-01-01" @default.
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- W2617255750 title "The cytotoxicity of minority benzo[c]phenanthridine alkaloids" @default.
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