FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617269411> ?p ?o ?g. }

• W2617269411 endingPage "42" @default.
• W2617269411 startingPage "35" @default.
• W2617269411 abstract "The present study aimed to evaluate the impact of small interfering RNA (siRNA) targeting of the survivin gene in human tumor cells and the effect of decreased survivin expression on the proliferation and apoptosis of tumor cells. Human tumor cell lines (MSA‑MB‑231, SGC‑7901, HeLa, A549, SK‑OV‑3 and Raji, PC‑3) were cultured in vitro and divided into three groups: survivin siRNA‑treated, scrambled negative control siRNA‑treated and an untreated control group. The level of survivin mRNA and protein expression was subsequently determined by reverse transcription‑quantitative polymerase chain reaction and western blot analysis, respectively. Cell proliferation was also examined by an MTT assay following transfection and the apoptotic rate of cells was detected by Hoechst and Annexin V/propidium iodide staining. It was observed that relative to the control group, expression of survivin mRNA and protein in the survivin siRNA‑treated group was significantly downregulated. Furthermore, siRNA targeting of survivin lead to the inhibition of tumor cell proliferation, as well as an increase in their apoptotic rate in vitro. These data suggest that survivin may be a potential tumor biomarker and a novel target for the treatment of cancer." @default.
• W2617269411 created "2017-06-05" @default.
• W2617269411 creator A5000828146 @default.
• W2617269411 creator A5018255460 @default.
• W2617269411 creator A5029290303 @default.
• W2617269411 creator A5032109840 @default.
• W2617269411 creator A5033039153 @default.
• W2617269411 creator A5038207049 @default.
• W2617269411 creator A5051318920 @default.
• W2617269411 creator A5056155368 @default.
• W2617269411 creator A5062613721 @default.
• W2617269411 date "2017-05-23" @default.
• W2617269411 modified "2023-09-27" @default.
• W2617269411 title "Small interfering RNA targeting of the survivin gene inhibits human tumor cell growth in vitro" @default.
• W2617269411 cites W149533676 @default.
• W2617269411 cites W1514680077 @default.
• W2617269411 cites W1662899239 @default.
• W2617269411 cites W1745634660 @default.
• W2617269411 cites W1870720170 @default.
• W2617269411 cites W1971263283 @default.
• W2617269411 cites W1977609115 @default.
• W2617269411 cites W1994725464 @default.
• W2617269411 cites W1999605095 @default.
• W2617269411 cites W2030891330 @default.
• W2617269411 cites W2031188419 @default.
• W2617269411 cites W2035523654 @default.
• W2617269411 cites W2039428694 @default.
• W2617269411 cites W2058615464 @default.
• W2617269411 cites W2062769503 @default.
• W2617269411 cites W2065392301 @default.
• W2617269411 cites W2083249633 @default.
• W2617269411 cites W2083540484 @default.
• W2617269411 cites W2107277218 @default.
• W2617269411 cites W2120686711 @default.
• W2617269411 cites W2124462326 @default.
• W2617269411 cites W2138436760 @default.
• W2617269411 cites W2155913947 @default.
• W2617269411 cites W2159579513 @default.
• W2617269411 cites W2167494923 @default.
• W2617269411 cites W2192080449 @default.
• W2617269411 cites W2317538561 @default.
• W2617269411 cites W2461279770 @default.
• W2617269411 cites W276665466 @default.
• W2617269411 doi "https://doi.org/10.3892/etm.2017.4501" @default.
• W2617269411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5488478" @default.
• W2617269411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28672890" @default.
• W2617269411 hasPublicationYear "2017" @default.
• W2617269411 type Work @default.
• W2617269411 sameAs 2617269411 @default.
• W2617269411 citedByCount "6" @default.
• W2617269411 countsByYear W26172694112017 @default.
• W2617269411 countsByYear W26172694112018 @default.
• W2617269411 countsByYear W26172694112019 @default.
• W2617269411 countsByYear W26172694112023 @default.
• W2617269411 crossrefType "journal-article" @default.
• W2617269411 hasAuthorship W2617269411A5000828146 @default.
• W2617269411 hasAuthorship W2617269411A5018255460 @default.
• W2617269411 hasAuthorship W2617269411A5029290303 @default.
• W2617269411 hasAuthorship W2617269411A5032109840 @default.
• W2617269411 hasAuthorship W2617269411A5033039153 @default.
• W2617269411 hasAuthorship W2617269411A5038207049 @default.
• W2617269411 hasAuthorship W2617269411A5051318920 @default.
• W2617269411 hasAuthorship W2617269411A5056155368 @default.
• W2617269411 hasAuthorship W2617269411A5062613721 @default.
• W2617269411 hasBestOaLocation W26172694111 @default.
• W2617269411 hasConcept C1491633281 @default.
• W2617269411 hasConcept C153911025 @default.
• W2617269411 hasConcept C185592680 @default.
• W2617269411 hasConcept C190283241 @default.
• W2617269411 hasConcept C22615655 @default.
• W2617269411 hasConcept C2775934118 @default.
• W2617269411 hasConcept C2775975398 @default.
• W2617269411 hasConcept C2777366897 @default.
• W2617269411 hasConcept C2780783641 @default.
• W2617269411 hasConcept C2781018059 @default.
• W2617269411 hasConcept C29537977 @default.
• W2617269411 hasConcept C31573885 @default.
• W2617269411 hasConcept C502942594 @default.
• W2617269411 hasConcept C54009773 @default.
• W2617269411 hasConcept C54355233 @default.
• W2617269411 hasConcept C55493867 @default.
• W2617269411 hasConcept C62112901 @default.
• W2617269411 hasConcept C81885089 @default.
• W2617269411 hasConcept C86803240 @default.
• W2617269411 hasConceptScore W2617269411C1491633281 @default.
• W2617269411 hasConceptScore W2617269411C153911025 @default.
• W2617269411 hasConceptScore W2617269411C185592680 @default.
• W2617269411 hasConceptScore W2617269411C190283241 @default.
• W2617269411 hasConceptScore W2617269411C22615655 @default.
• W2617269411 hasConceptScore W2617269411C2775934118 @default.
• W2617269411 hasConceptScore W2617269411C2775975398 @default.
• W2617269411 hasConceptScore W2617269411C2777366897 @default.
• W2617269411 hasConceptScore W2617269411C2780783641 @default.
• W2617269411 hasConceptScore W2617269411C2781018059 @default.
• W2617269411 hasConceptScore W2617269411C29537977 @default.
• W2617269411 hasConceptScore W2617269411C31573885 @default.
• W2617269411 hasConceptScore W2617269411C502942594 @default.
• W2617269411 hasConceptScore W2617269411C54009773 @default.

• next