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• W2617317963 abstract "Matrix metalloproteinases (MMPs) play a crucial role in the degradation of the extracellular matrix and pathological progression of osteoarthritis (OA). Omentin-1 is a newly identified anti-inflammatory adipokine. Little information regarding the protective effects of omentin-1 in OA has been reported before. In the current study, our results indicated that omentin-1 suppressed expression of MMP-1, MMP-3, and MMP-13 induced by the proinflammatory cytokine interleukin-1β (IL-1β) at both the mRNA and protein levels in human chondrocytes. Importantly, administration of omentin-1 abolished IL-1β-induced degradation of type II collagen (Col II) and aggrecan, the two major extracellular matrix components in articular cartilage, in a dose-dependent manner. Mechanistically, omentin-1 ameliorated the expression of interferon regulatory factor 1 (IRF-1) by blocking the JAK-2/STAT3 pathway. Our results indicate that omentin-1 may have a potential chondroprotective therapeutic capacity." @default.
• W2617317963 created "2017-06-05" @default.
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• W2617317963 date "2017-08-01" @default.
• W2617317963 modified "2023-09-23" @default.
• W2617317963 title "Omentin-1 prevents cartilage matrix destruction by regulating matrix metalloproteinases" @default.
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• W2617317963 doi "https://doi.org/10.1016/j.biopha.2017.05.059" @default.
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