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• W2617334468 abstract "SUMMARY Multiciliated cells (MCCs) drive fluid flow in diverse tubular organs and are essential for development and homeostasis of the vertebrate central nervous system, airway, and reproductive tracts. These cells are characterized by dozens or hundreds of long, motile cilia that beat in a coordinated and polarized manner (Brooks and Wallingford, 2014). In recent years, genomic studies have not only elucidated the transcriptional hierarchy for MCC specification, but also identified myriad new proteins that govern MCC ciliogenesis, cilia beating, or cilia polarization (e.g. (Choksi et al., 2014b; Chung et al., 2014; Hoh et al., 2012; Ma et al., 2014; Treutlein et al., 2014)). Interestingly, this burst of genomic data has also highlighted the obvious importance of the “ignorome,” that large fraction of vertebrate genes that remain only poorly characterized (Pandey et al., 2014). Understanding the function of novel proteins with little prior history of study presents a special challenge, especially when faced with large numbers of such proteins. Here, we explored the MCC ignorome by defining the subcellular localization of 260 poorly defined proteins in vertebrate MCCs in vivo . Moreover, functional analyses that arose from results of the screen provide novel insights into the mechanisms by which the actin cytoskeleton simultaneously influences diverse aspects of MCC biology, including basal body docking, and ciliogenesis." @default.
• W2617334468 created "2017-06-05" @default.
• W2617334468 creator A5035289755 @default.
• W2617334468 creator A5054294894 @default.
• W2617334468 creator A5056470087 @default.
• W2617334468 creator A5062328598 @default.
• W2617334468 creator A5079751395 @default.
• W2617334468 date "2017-05-23" @default.
• W2617334468 modified "2023-09-25" @default.
• W2617334468 title "High-content protein localization screening in vivo reveals novel regulators of multiciliated cell development and function" @default.
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• W2617334468 doi "https://doi.org/10.1101/141234" @default.
• W2617334468 hasPublicationYear "2017" @default.
• W2617334468 type Work @default.
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• W2617334468 hasAuthorship W2617334468A5035289755 @default.

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