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- W2617368330 endingPage "49930" @default.
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- W2617368330 abstract "Breast cancer (BC) is the most common diagnosed cancer and the leading cause of cancer death in women worldwide. There is an obvious need for a better understanding of BC biology. Alterations in the serum metabolome of BC patients have been identified but their clinical significance remains elusive. We evaluated by 1H-Nuclear Magnetic Resonance (1H-NMR) spectroscopy, filtered plasma metabolome of 50 early (EBC) and 15 metastatic BC (MBC) patients. Using Principal Component Analysis, Partial Least-Squares Discriminant Analysis and Hierarchical Clustering we show that plasma levels of glucose, lactate, pyruvate, alanine, leucine, isoleucine, glutamate, glutamine, valine, lysine, glycine, threonine, tyrosine, phenylalanine, acetate, acetoacetate, β-hydroxy-butyrate, urea, creatine and creatinine are modulated across patients clusters. In particular lactate levels are inversely correlated with the tumor size in the EBC cohort (Pearson correlation r = -0.309; p = 0.044). We suggest that, in BC patients, tumor cells could induce modulation of the whole patient's metabolism even at early stages. If confirmed in a lager study these observations could be of clinical importance." @default.
- W2617368330 created "2017-06-05" @default.
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- W2617368330 date "2017-05-30" @default.
- W2617368330 modified "2023-10-16" @default.
- W2617368330 title "Does the 1H-NMR plasma metabolome reflect the host-tumor interactions in human breast cancer?" @default.
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- W2617368330 doi "https://doi.org/10.18632/oncotarget.18307" @default.
- W2617368330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5564817" @default.
- W2617368330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28611296" @default.
- W2617368330 hasPublicationYear "2017" @default.
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