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- W2617369464 abstract "ABSTRACT The tet39 tetracycline resistance determinant and the macrolide resistance genes msrE and mphE were found in an 18.2-kb plasmid, pS30-1, recovered from a global clone 2 (GC2) Acinetobacter baumannii isolate from Singapore, that conferred resistance to tetracycline and erythromycin. pS30-1 also contains mobA and mobC genes encoding MOB Q family proteins, but attempts to mobilize pS30-1 utilizing a coresident conjugative repAci6 plasmid were unsuccessful. Eight p dif sites, consisting of inversely oriented binding sites for the XerC and XerD recombinases separated by 6 bp, were detected in pS30-1. The tet39 determinant and the msrE-mphE gene pair are each surrounded by two p dif sites in inverse orientation. Identical regions in different contexts and many previously unnoticed p dif sites were found in a number of different plasmids in GenBank, showing that the tet39 and msrE-mphE dif modules are mobile. A putative toxin/antitoxin system, a gene encoding a serine recombinase, and open reading frames of unknown function were also part of dif modules in pS30-1. In general, modules with internal XerC or XerD sites alternate. Two copies of IS Ajo2-1 (94% identical to IS Ajo2 ) in pS30-1 were inserted 5 bp from a XerC site, and this appears to be the preferred insertion site for this insertion sequence (IS) group. Apparently, Acinetobacter plasmids exploit the Acinetobacter XerC-XerD recombinases to mobilize DNA units containing resistance and other genes, via an uncharacterized mechanism. The tet39 and msrE-mphE dif modules add to the oxa24 module and the oxa58 module redefined here, bringing the total of resistance gene-containing dif modules in Acinetobacter plasmids to four." @default.
- W2617369464 created "2017-06-05" @default.
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- W2617369464 date "2017-08-01" @default.
- W2617369464 modified "2023-10-17" @default.
- W2617369464 title "The <i>tet39</i> Determinant and the <i>msrE-mphE</i> Genes in Acinetobacter Plasmids Are Each Part of Discrete Modules Flanked by Inversely Oriented p <i>dif</i> (XerC-XerD) Sites" @default.
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- W2617369464 doi "https://doi.org/10.1128/aac.00780-17" @default.
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