FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617375743> ?p ?o ?g. }

• W2617375743 endingPage "e0177192" @default.
• W2617375743 startingPage "e0177192" @default.
• W2617375743 abstract "Renal vascular development is a coordinated process that requires ordered endothelial cell proliferation, migration, intercellular adhesion, and morphogenesis. In recent decades, studies have defined the pivotal role of endothelial receptor tyrosine kinases (RPTKs) in the development and maintenance of renal vasculature. However, the expression and the role of receptor tyrosine phosphatases (RPTPs) in renal endothelium are poorly understood, though coupled and counterbalancing roles of RPTKs and RPTPs are well defined in other systems. In this study, we evaluated the promoter activity and immunolocalization of two endothelial RPTPs, VE-PTP and PTPμ, in developing and adult renal vasculature using the heterozygous LacZ knock-in mice and specific antibodies. In adult kidneys, both VE-PTP and PTPμ were expressed in the endothelium of arterial, glomerular, and medullary vessels, while their expression was highly limited in peritubular capillaries and venous endothelium. VE-PTP and PTPμ promoter activity was also observed in medullary tubular segments in adult kidneys. In embryonic (E12.5, E13.5, E15.5, E17.5) and postnatal (P0, P3, P7) kidneys, these RPTPs were expressed in ingrowing renal arteries, developing glomerular microvasculature (as early as the S-shaped stage), and medullary vessels. Their expression became more evident as the vasculatures matured. Peritubular capillary expression of VE-PTP was also noted in embryonic and postnatal kidneys. Compared to VE-PTP, PTPμ immunoreactivity was relatively limited in embryonic and neonatal renal vasculature and evident immunoreactivity was observed from the P3 stage. These findings indicate 1) VE-PTP and PTPμ are expressed in endothelium of arterial, glomerular, and medullary renal vasculature, 2) their expression increases as renal vascular development proceeds, suggesting that these RPTPs play a role in maturation and maintenance of these vasculatures, and 3) peritubular capillary VE-PTP expression is down-regulated in adult kidneys, suggesting a role of VE-PTP in the development of peritubular capillaries." @default.
• W2617375743 created "2017-06-05" @default.
• W2617375743 creator A5001798874 @default.
• W2617375743 creator A5009450784 @default.
• W2617375743 creator A5036682345 @default.
• W2617375743 creator A5037983939 @default.
• W2617375743 creator A5045817572 @default.
• W2617375743 creator A5046196948 @default.
• W2617375743 creator A5058539484 @default.
• W2617375743 creator A5063808473 @default.
• W2617375743 creator A5075712626 @default.
• W2617375743 creator A5078552899 @default.
• W2617375743 creator A5085672493 @default.
• W2617375743 creator A5086504375 @default.
• W2617375743 date "2017-05-25" @default.
• W2617375743 modified "2023-09-27" @default.
• W2617375743 title "Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature" @default.
• W2617375743 cites W1581644263 @default.
• W2617375743 cites W1674557579 @default.
• W2617375743 cites W1823155666 @default.
• W2617375743 cites W1953282120 @default.
• W2617375743 cites W1971134298 @default.
• W2617375743 cites W1971968805 @default.
• W2617375743 cites W1982152757 @default.
• W2617375743 cites W1983590517 @default.
• W2617375743 cites W1989326196 @default.
• W2617375743 cites W1994599795 @default.
• W2617375743 cites W2004736132 @default.
• W2617375743 cites W2020009240 @default.
• W2617375743 cites W2023284816 @default.
• W2617375743 cites W2030135968 @default.
• W2617375743 cites W2041762633 @default.
• W2617375743 cites W2053827428 @default.
• W2617375743 cites W2056383041 @default.
• W2617375743 cites W2058078164 @default.
• W2617375743 cites W2059376637 @default.
• W2617375743 cites W2059452371 @default.
• W2617375743 cites W2064784101 @default.
• W2617375743 cites W2092946806 @default.
• W2617375743 cites W2096093067 @default.
• W2617375743 cites W2096756834 @default.
• W2617375743 cites W2112237544 @default.
• W2617375743 cites W2120310214 @default.
• W2617375743 cites W2124298587 @default.
• W2617375743 cites W2126281673 @default.
• W2617375743 cites W2126945510 @default.
• W2617375743 cites W2128749739 @default.
• W2617375743 cites W2136131782 @default.
• W2617375743 cites W2136494392 @default.
• W2617375743 cites W2159102915 @default.
• W2617375743 cites W2162152141 @default.
• W2617375743 cites W2190979306 @default.
• W2617375743 cites W2290924629 @default.
• W2617375743 cites W2411082061 @default.
• W2617375743 cites W4232085987 @default.
• W2617375743 cites W4250017257 @default.
• W2617375743 doi "https://doi.org/10.1371/journal.pone.0177192" @default.
• W2617375743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5444631" @default.
• W2617375743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28542220" @default.
• W2617375743 hasPublicationYear "2017" @default.
• W2617375743 type Work @default.
• W2617375743 sameAs 2617375743 @default.
• W2617375743 citedByCount "8" @default.
• W2617375743 countsByYear W26173757432019 @default.
• W2617375743 countsByYear W26173757432020 @default.
• W2617375743 countsByYear W26173757432021 @default.
• W2617375743 countsByYear W26173757432022 @default.
• W2617375743 crossrefType "journal-article" @default.
• W2617375743 hasAuthorship W2617375743A5001798874 @default.
• W2617375743 hasAuthorship W2617375743A5009450784 @default.
• W2617375743 hasAuthorship W2617375743A5036682345 @default.
• W2617375743 hasAuthorship W2617375743A5037983939 @default.
• W2617375743 hasAuthorship W2617375743A5045817572 @default.
• W2617375743 hasAuthorship W2617375743A5046196948 @default.
• W2617375743 hasAuthorship W2617375743A5058539484 @default.
• W2617375743 hasAuthorship W2617375743A5063808473 @default.
• W2617375743 hasAuthorship W2617375743A5075712626 @default.
• W2617375743 hasAuthorship W2617375743A5078552899 @default.
• W2617375743 hasAuthorship W2617375743A5085672493 @default.
• W2617375743 hasAuthorship W2617375743A5086504375 @default.
• W2617375743 hasBestOaLocation W26173757431 @default.
• W2617375743 hasConcept C126322002 @default.
• W2617375743 hasConcept C134018914 @default.
• W2617375743 hasConcept C170493617 @default.
• W2617375743 hasConcept C2776992346 @default.
• W2617375743 hasConcept C2780091579 @default.
• W2617375743 hasConcept C71924100 @default.
• W2617375743 hasConcept C85528070 @default.
• W2617375743 hasConcept C86803240 @default.
• W2617375743 hasConcept C95444343 @default.
• W2617375743 hasConceptScore W2617375743C126322002 @default.
• W2617375743 hasConceptScore W2617375743C134018914 @default.
• W2617375743 hasConceptScore W2617375743C170493617 @default.
• W2617375743 hasConceptScore W2617375743C2776992346 @default.
• W2617375743 hasConceptScore W2617375743C2780091579 @default.
• W2617375743 hasConceptScore W2617375743C71924100 @default.
• W2617375743 hasConceptScore W2617375743C85528070 @default.
• W2617375743 hasConceptScore W2617375743C86803240 @default.

• next