Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617383260> ?p ?o ?g. }
- W2617383260 endingPage "18" @default.
- W2617383260 startingPage "1" @default.
- W2617383260 abstract "Cellular interaction is inevitable in the pathomechanism of human disease. Formation of heterotypic cellular aggregates, between distinct cells of hematopoietic and nonhematopoietic origin, may be involved in events leading to inflammation and the complex process of cancer progression. Among adhesion receptors, the family of selectins with their ligands have been considered as one of the major contributors to cell-cell interactions. Consequently, the inhibition of the interplay between selectins and their ligands may have potential therapeutic benefits. In this review, we focus on the current evidence on the selectins as crucial modulators of inflammatory, thrombotic, and malignant disorders. Knowing that there is promiscuity in selectin binding, we outline the importance of a key protein that serves as a ligand for all selectins. This dimeric mucin, the P-selectin glycoprotein ligand 1 (PSGL-1), has emerged as a major player in inflammation, thrombus, and cancer development. We discuss the interaction of PSGL-1 with various selectins in physiological and pathological processes with particular emphasis on mechanisms that lead to severe disease." @default.
- W2617383260 created "2017-06-05" @default.
- W2617383260 creator A5034769783 @default.
- W2617383260 creator A5040747934 @default.
- W2617383260 date "2017-01-01" @default.
- W2617383260 modified "2023-10-04" @default.
- W2617383260 title "The Interaction of Selectins and PSGL-1 as a Key Component in Thrombus Formation and Cancer Progression" @default.
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