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• W2617403669 abstract "Cancer/testis antigen (CTAg) expression is restricted to spermatogenic cells in an immune-privileged site within the testis. However, these proteins are expressed aberrantly by malignant cells and T-cell responses against CTAgs develop in many cancer patients. We investigated the prevalence, magnitude and phenotype of CTAg-specific T cells in the blood of patients with testicular germ cell tumors (TGCTs). CD8+ and CD4+ T-cell responses against MAGE-A family antigens were present in 44% (20/45) of patients' samples assayed by ex vivo IFN-γ ELISPOT. The presence of MAGE-specific CD8+ T cells was further determined following short-term in vitro expansion through the use of pMHC-I multimers containing known immunogenic peptides. Longitudinal analysis revealed that the frequency of MAGE-specific T cells decreased by 89% following orchidectomy suggesting that persistence of tumor antigen is required to sustain CTAg-specific T-cell immunity. Notably, this decrease correlated with a decline in the global effector/memory T-cell pool following treatment. Spontaneous T-cell immunity against CTAg proteins therefore develops in many patients with testicular cancer and may play an important role in the excellent clinical outcome of patients with this tumor subtype." @default.
• W2617403669 created "2017-06-05" @default.
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• W2617403669 date "2017-06-26" @default.
• W2617403669 modified "2023-10-17" @default.
• W2617403669 title "Spontaneous CD4⁺and CD8⁺T-cell responses directed against cancer testis antigens are present in the peripheral blood of testicular cancer patients" @default.
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• W2617403669 doi "https://doi.org/10.1002/eji.201646898" @default.
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• W2617403669 hasPublicationYear "2017" @default.
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