FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617442600> ?p ?o ?g. }

• W2617442600 endingPage "633" @default.
• W2617442600 startingPage "629" @default.
• W2617442600 abstract "Cellular oxidative stress, inflammatory responses, and immunogenic events are involved in pathogenesis of idiopathic nephrotic syndrome (INS); however, the exact mechanism remains unknown. We examined NADPH oxidase (NOX) activity and platelet-derived growth factor (PDGF)-induced DNA synthesis in peripheral blood lymphocytes (PBL) of patients with INS. PBL from 15 patients with INS and 15 age- and gender-matched controls were isolated, and enzyme activities of NOX, catalase, and superoxide dismutase (SOD) were measured along with the assay of malondialdehyde levels and bromo-deoxyuridine incorporation. Protein expression of NOX-1 was measured using western blot analysis. Patients with INS had significantly (P<0.01) higher NOX activity and increased protein expression of NOX-1 in PBL as compared with controls. Catalase and SOD activities were markedly lower with lipid peroxide levels significantly (P<0.01) increased in patients with INS. Ex vivo DNA synthesis in PDGF-stimulated PBL was significantly (P<0.01) reduced in patients with INS; however, diphenyliodonium, an inhibitor of NOX, markedly corrected impairment in growth factor-induced BrdU incorporation. These results show that NOX activation might have a role in regulation of lymphocytic activity in patients with INS through the impairment of PDGF mitogenic function and might contribute toward pathogenesis of nephrotic syndrome." @default.
• W2617442600 created "2017-06-05" @default.
• W2617442600 creator A5004121123 @default.
• W2617442600 creator A5035221725 @default.
• W2617442600 date "2017-06-14" @default.
• W2617442600 modified "2023-10-17" @default.
• W2617442600 title "NOX-mediated impairment of PDGF-induced DNA synthesis in peripheral blood lymphocytes of children with idiopathic nephrotic syndrome" @default.
• W2617442600 cites W1500603045 @default.
• W2617442600 cites W1776917887 @default.
• W2617442600 cites W1803615068 @default.
• W2617442600 cites W1940122864 @default.
• W2617442600 cites W1965979431 @default.
• W2617442600 cites W1976555160 @default.
• W2617442600 cites W1982433639 @default.
• W2617442600 cites W2004539338 @default.
• W2617442600 cites W2009772673 @default.
• W2617442600 cites W2013959735 @default.
• W2617442600 cites W2015029205 @default.
• W2617442600 cites W2017170667 @default.
• W2617442600 cites W2042332509 @default.
• W2617442600 cites W2042752364 @default.
• W2617442600 cites W2056392169 @default.
• W2617442600 cites W2068168605 @default.
• W2617442600 cites W2095787634 @default.
• W2617442600 cites W2106913297 @default.
• W2617442600 cites W2111644571 @default.
• W2617442600 cites W2136943396 @default.
• W2617442600 cites W2160274996 @default.
• W2617442600 cites W2160430974 @default.
• W2617442600 cites W2160829089 @default.
• W2617442600 cites W2171652603 @default.
• W2617442600 cites W2594454279 @default.
• W2617442600 cites W4210848327 @default.
• W2617442600 doi "https://doi.org/10.1038/pr.2017.122" @default.
• W2617442600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28613279" @default.
• W2617442600 hasPublicationYear "2017" @default.
• W2617442600 type Work @default.
• W2617442600 sameAs 2617442600 @default.
• W2617442600 citedByCount "4" @default.
• W2617442600 countsByYear W26174426002019 @default.
• W2617442600 countsByYear W26174426002021 @default.
• W2617442600 countsByYear W26174426002022 @default.
• W2617442600 crossrefType "journal-article" @default.
• W2617442600 hasAuthorship W2617442600A5004121123 @default.
• W2617442600 hasAuthorship W2617442600A5035221725 @default.
• W2617442600 hasBestOaLocation W26174426001 @default.
• W2617442600 hasConcept C104317684 @default.
• W2617442600 hasConcept C126322002 @default.
• W2617442600 hasConcept C134018914 @default.
• W2617442600 hasConcept C143425029 @default.
• W2617442600 hasConcept C153911025 @default.
• W2617442600 hasConcept C185592680 @default.
• W2617442600 hasConcept C203014093 @default.
• W2617442600 hasConcept C2775838275 @default.
• W2617442600 hasConcept C2776151105 @default.
• W2617442600 hasConcept C2776415932 @default.
• W2617442600 hasConcept C2778979269 @default.
• W2617442600 hasConcept C2779719074 @default.
• W2617442600 hasConcept C2780942790 @default.
• W2617442600 hasConcept C552990157 @default.
• W2617442600 hasConcept C55493867 @default.
• W2617442600 hasConcept C71924100 @default.
• W2617442600 hasConcept C86803240 @default.
• W2617442600 hasConceptScore W2617442600C104317684 @default.
• W2617442600 hasConceptScore W2617442600C126322002 @default.
• W2617442600 hasConceptScore W2617442600C134018914 @default.
• W2617442600 hasConceptScore W2617442600C143425029 @default.
• W2617442600 hasConceptScore W2617442600C153911025 @default.
• W2617442600 hasConceptScore W2617442600C185592680 @default.
• W2617442600 hasConceptScore W2617442600C203014093 @default.
• W2617442600 hasConceptScore W2617442600C2775838275 @default.
• W2617442600 hasConceptScore W2617442600C2776151105 @default.
• W2617442600 hasConceptScore W2617442600C2776415932 @default.
• W2617442600 hasConceptScore W2617442600C2778979269 @default.
• W2617442600 hasConceptScore W2617442600C2779719074 @default.
• W2617442600 hasConceptScore W2617442600C2780942790 @default.
• W2617442600 hasConceptScore W2617442600C552990157 @default.
• W2617442600 hasConceptScore W2617442600C55493867 @default.
• W2617442600 hasConceptScore W2617442600C71924100 @default.
• W2617442600 hasConceptScore W2617442600C86803240 @default.
• W2617442600 hasIssue "4" @default.
• W2617442600 hasLocation W26174426001 @default.
• W2617442600 hasLocation W26174426002 @default.
• W2617442600 hasOpenAccess W2617442600 @default.
• W2617442600 hasPrimaryLocation W26174426001 @default.
• W2617442600 hasRelatedWork W1990221920 @default.
• W2617442600 hasRelatedWork W2027681935 @default.
• W2617442600 hasRelatedWork W2042147930 @default.
• W2617442600 hasRelatedWork W2048985548 @default.
• W2617442600 hasRelatedWork W2139861763 @default.
• W2617442600 hasRelatedWork W2367305450 @default.
• W2617442600 hasRelatedWork W2748952813 @default.
• W2617442600 hasRelatedWork W2966747629 @default.
• W2617442600 hasRelatedWork W3035688912 @default.
• W2617442600 hasRelatedWork W3031685627 @default.
• W2617442600 hasVolume "82" @default.
• W2617442600 isParatext "false" @default.
• W2617442600 isRetracted "false" @default.

• next