Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617462810> ?p ?o ?g. }
- W2617462810 abstract "Abstract Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control the production of phosphatidylinositol 3-phosphate (PtdIns3P), a prerequisite for autophagosome formation. Here we report that WIPI3 and WIPI4 scaffold the signal control of autophagy upstream of PtdIns3P production and have a role in the PtdIns3P effector function of WIPI1-WIPI2 at nascent autophagosomes. In response to LKB1-mediated AMPK stimulation, WIPI4-ATG2 is released from a WIPI4-ATG2/AMPK-ULK1 complex and translocates to nascent autophagosomes, controlling their size, to which WIPI3, in complex with FIP200, also contributes. Upstream, WIPI3 associates with AMPK-activated TSC complex at lysosomes, regulating mTOR. Our WIPI interactome analysis reveals the scaffold functions of WIPI proteins interconnecting autophagy signal control and autophagosome formation. Our functional kinase screen uncovers a novel regulatory link between LKB1-mediated AMPK stimulation that produces a direct signal via WIPI4, and we show that the AMPK-related kinases NUAK2 and BRSK2 regulate autophagy through WIPI4." @default.
- W2617462810 created "2017-06-05" @default.
- W2617462810 creator A5006098859 @default.
- W2617462810 creator A5006492057 @default.
- W2617462810 creator A5008347489 @default.
- W2617462810 creator A5017016617 @default.
- W2617462810 creator A5020867690 @default.
- W2617462810 creator A5024631305 @default.
- W2617462810 creator A5061480346 @default.
- W2617462810 creator A5064095062 @default.
- W2617462810 creator A5074552442 @default.
- W2617462810 creator A5083327817 @default.
- W2617462810 creator A5085238149 @default.
- W2617462810 creator A5086762006 @default.
- W2617462810 date "2017-05-31" @default.
- W2617462810 modified "2023-10-12" @default.
- W2617462810 title "WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy" @default.
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