FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617481267> ?p ?o ?g. }

• W2617481267 endingPage "845" @default.
• W2617481267 startingPage "833" @default.
• W2617481267 abstract "The novel class of dual-family immunophilins (henceforth abbreviated as DFI) represents naturally occurring chimera of classical FK506-binding protein (FKBP) and cyclophilin (CYN), connected by a flexible linker that may include a three-unit tetratricopeptide (TPR) repeat. Here, I report a comprehensive analysis of all current DFI sequences and their host organisms. DFIs are of two kinds: CFBP (cyclosporin- and FK506-binding protein) and FCBP (FK506- and cyclosporin-binding protein), found in eukaryotes. The CFBP type occurs in select bacteria that are mostly extremophiles, such as psychrophilic, thermophilic, halophilic, and sulfur-reducing. Essentially all DFI organisms are unicellular. I suggest that DFIs are specialized bifunctional chaperones that use their flexible interdomain linker to associate with large polypeptides or multisubunit megacomplexes to promote simultaneous folding or renaturation of two clients in proximity, essential in stressful and denaturing environments. Analysis of sequence homology and predicted 3D structures of the FKBP and CYN domains as well as the TPR linkers upheld the modular nature of the DFIs and revealed the uniqueness of their TPR domain. The CFBP and FCBP genes appear to have evolved in parallel pathways with no obvious single common ancestor. The occurrence of both types of DFI in multiple unrelated phylogenetic clades supported their selection in metabolic and environmental niche roles rather than a traditional taxonomic relationship. Nonetheless, organisms with these rare immunophilins may define an operational taxonomic unit (OTU) bound by the commonality of chaperone function." @default.
• W2617481267 created "2017-06-05" @default.
• W2617481267 creator A5007213279 @default.
• W2617481267 date "2017-05-31" @default.
• W2617481267 modified "2023-10-17" @default.
• W2617481267 title "On the role, ecology, phylogeny, and structure of dual-family immunophilins" @default.
• W2617481267 cites W1568279110 @default.
• W2617481267 cites W1588911128 @default.
• W2617481267 cites W1888500830 @default.
• W2617481267 cites W1955276614 @default.
• W2617481267 cites W1963898183 @default.
• W2617481267 cites W1964990008 @default.
• W2617481267 cites W1965874164 @default.
• W2617481267 cites W1968339029 @default.
• W2617481267 cites W1985605910 @default.
• W2617481267 cites W1985648234 @default.
• W2617481267 cites W1986544564 @default.
• W2617481267 cites W1987134040 @default.
• W2617481267 cites W1998731636 @default.
• W2617481267 cites W2000277994 @default.
• W2617481267 cites W2018430650 @default.
• W2617481267 cites W2025720366 @default.
• W2617481267 cites W2026258231 @default.
• W2617481267 cites W2030498531 @default.
• W2617481267 cites W2031748911 @default.
• W2617481267 cites W2034832242 @default.
• W2617481267 cites W2041643423 @default.
• W2617481267 cites W2049631853 @default.
• W2617481267 cites W2049667694 @default.
• W2617481267 cites W2050217945 @default.
• W2617481267 cites W2059534367 @default.
• W2617481267 cites W2060595324 @default.
• W2617481267 cites W2072966557 @default.
• W2617481267 cites W2077016339 @default.
• W2617481267 cites W2077601582 @default.
• W2617481267 cites W2081214829 @default.
• W2617481267 cites W2081425248 @default.
• W2617481267 cites W2081626827 @default.
• W2617481267 cites W2081805738 @default.
• W2617481267 cites W2083660844 @default.
• W2617481267 cites W2089857321 @default.
• W2617481267 cites W2092106545 @default.
• W2617481267 cites W2093707886 @default.
• W2617481267 cites W2095805667 @default.
• W2617481267 cites W2110040181 @default.
• W2617481267 cites W2110635373 @default.
• W2617481267 cites W2113006462 @default.
• W2617481267 cites W2114349883 @default.
• W2617481267 cites W2114691940 @default.
• W2617481267 cites W2115981539 @default.
• W2617481267 cites W2116231416 @default.
• W2617481267 cites W2121207910 @default.
• W2617481267 cites W2121380014 @default.
• W2617481267 cites W2124675240 @default.
• W2617481267 cites W2125774147 @default.
• W2617481267 cites W2127322768 @default.
• W2617481267 cites W2131177458 @default.
• W2617481267 cites W2134628018 @default.
• W2617481267 cites W2138150298 @default.
• W2617481267 cites W2141433232 @default.
• W2617481267 cites W2145848565 @default.
• W2617481267 cites W2146256775 @default.
• W2617481267 cites W2147637736 @default.
• W2617481267 cites W2150658204 @default.
• W2617481267 cites W2153451394 @default.
• W2617481267 cites W2154603697 @default.
• W2617481267 cites W2157721183 @default.
• W2617481267 cites W2158266834 @default.
• W2617481267 cites W2160392709 @default.
• W2617481267 cites W2160637307 @default.
• W2617481267 cites W2162117262 @default.
• W2617481267 cites W2166865790 @default.
• W2617481267 cites W2167424059 @default.
• W2617481267 cites W2167640017 @default.
• W2617481267 cites W2238888716 @default.
• W2617481267 cites W2273454618 @default.
• W2617481267 cites W2406480556 @default.
• W2617481267 cites W2408829075 @default.
• W2617481267 cites W2484933504 @default.
• W2617481267 cites W2520355709 @default.
• W2617481267 cites W4246746412 @default.
• W2617481267 doi "https://doi.org/10.1007/s12192-017-0813-x" @default.
• W2617481267 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5655371" @default.
• W2617481267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28567569" @default.
• W2617481267 hasPublicationYear "2017" @default.
• W2617481267 type Work @default.
• W2617481267 sameAs 2617481267 @default.
• W2617481267 citedByCount "8" @default.
• W2617481267 countsByYear W26174812672017 @default.
• W2617481267 countsByYear W26174812672018 @default.
• W2617481267 countsByYear W26174812672019 @default.
• W2617481267 countsByYear W26174812672020 @default.
• W2617481267 countsByYear W26174812672022 @default.
• W2617481267 countsByYear W26174812672023 @default.
• W2617481267 crossrefType "journal-article" @default.
• W2617481267 hasAuthorship W2617481267A5007213279 @default.
• W2617481267 hasBestOaLocation W26174812672 @default.
• W2617481267 hasConcept C104317684 @default.

• next