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- W2617485792 abstract "Yearly more than 15 million babies are born premature (<37 weeks gestational age), accounting for more than 1 in 10 births worldwide. Lung injury caused by maternal chorioamnionitis or preeclampsia, postnatal ventilation, hyperoxia or inflammation can lead to the development of bronchopulmonary dysplasia (BPD), one of the most common adverse outcomes in these preterm neonates. BPD patients have an arrest in alveolar and microvascular development and more frequently develop asthma and early-onset emphysema as they age. Understanding how the alveoli develop, and repair and regenerate after injury is critical for the development of therapies, as unfortunately there still is no cure for BPD. In this review we aim to provide an overview of emerging new concepts in the understanding of perinatal lung development and injury from a molecular and cellular point of view and how this is paving the way for new therapeutic options to prevent or treat BPD, as well as a reflection on current treatment procedures." @default.
- W2617485792 created "2017-06-05" @default.
- W2617485792 creator A5026235423 @default.
- W2617485792 creator A5027311372 @default.
- W2617485792 creator A5047421462 @default.
- W2617485792 creator A5052922674 @default.
- W2617485792 creator A5073013772 @default.
- W2617485792 date "2017-05-22" @default.
- W2617485792 modified "2023-09-27" @default.
- W2617485792 title "The Future of Bronchopulmonary Dysplasia: Emerging Pathophysiological Concepts and Potential New Avenues of Treatment" @default.
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