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- W2617496581 abstract "The causes of oral diseases of animals have received relatively little attention in recent decades compared to analogous diseases in humans, despite their frequent occurrence and the pain and discomfort caused. This presentation will summarise recent research conducted on the microbial and immune basis of oral diseases of small companion and large farm animals. Feline chronic gingivostomatitis is a chronic oral inflammatory disease that causes severe pain and distress and is challenging to treat, often necessitating total dental extraction. Recent work on the identification of putative pathogens and their interaction with the innate immune system will be presented and discussed. Equine periodontitis is a common and painful condition, whose prevalence increases with age, which can lead to tooth loss. Its aetiopathogenesis remains poorly understood despite recent increased awareness of this disorder amongst the veterinary profession. Bacteria and their interaction with the innate immune system is known to play an important role in human periodontitis, but such a role in equine periodontitis has not yet been examined. Data on the microbiomes associated with equine periodontitis and oral health, highlighting key differences, will be presented. Changes in Toll-like receptor and cytokine expression profiles between health and disease will also be discussed. There is little known about dental disease in cattle and no routine dental treatments currently exist. Although cattle are of worldwide economic importance in the dairy and beef industries, their dentition has not been investigated as thoroughly as that in other herbivores and small animals. We have recently shown that periodontitis is frequently found in slaughtered cattle. Data will be presented on the microbiomes associated with bovine periodontitis and oral health. Knowledge of pathogens involved in the aetiopathogenesis of animal oral diseases and their interaction with the host immune system will form the basis for future development of novel therapies for their prevention, treatment and management." @default.
- W2617496581 created "2017-06-05" @default.
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- W2617496581 date "2016-10-30" @default.
- W2617496581 modified "2023-09-26" @default.
- W2617496581 title "Oral diseases of animals – peering into the unknown" @default.
- W2617496581 hasPublicationYear "2016" @default.
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