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• W2617502386 abstract "144 Adhesive organelles of bacterial pathogens are crucial virulence factors, mediating attachment to the target cells of their hosts and initiating infectious process. They also are involved in biofilm formation making bacteria more resistant to immune response. Gram-negative pathogens possess two major classes of proteinaceous adhesins [1]: • The fimbrial adhesive organelles, represented by the linear homopolymers or hete ro polymers (up to 7 distinct subunits) of hundreds to thousands of protein subunits; • The non-fimbrial adhesins consisted of a single protein or homotrimers. The superfamily of fimbrial organelles, assembled by the chaperone/usher (CU) machinery, is divided in two functionally distinct families: monoadhesins and polyadhesins [1, 2]. Monoadhesins comprises in main the thick rigid and thin flexible adhesive pili of a complex subunit composition (up to 7 distinct subunits), which typically display only one adhesive domain on the tip of the pilus. The assembly of monoadhesins is assisted with the FGS (having a short F1-G1 loop) class of periplasmic chaperones [3, 4]. The monoadhesins are encoded in main by the gene clusters of the γ1-, γ2-, γ4-, and γ-monophyletic groups [5]. Polyadhesins, typically, have non-pilus, amorphous or capsule-like morphology. They either comprise homopolymers, which consist of only one type of subunit, or heteropolymers, which consist up to 6 distinct subunits. The notable property of polyadhesins is that all subunits of homopolymers or one of the main structural subunits of heteropolymers possesses one or two independent binding sites specific to different host cell receptors [1, 2]. Assembly of one subfamily of polyadhesins is assisted with the FGL (having a long F1-G1 loop) class of periplasmic chaperones [3, 4]. FGL chaperone-assembled polyadhesins are encoded exclusively by the gene cluster of the UDK 577.083.3+579.84" @default.
• W2617502386 created "2017-06-05" @default.
• W2617502386 creator A5070846387 @default.
• W2617502386 date "2013-01-01" @default.
• W2617502386 modified "2023-09-25" @default.
• W2617502386 title "POLYADHESINS: AN ARMORY OF GRAM--NEGATIVE PATHOGENS FOR PENETRATION THROUGH THE IMMUNE SHIELD" @default.
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• W2617502386 doi "https://doi.org/10.15407/biotech6.04.144" @default.
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