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• W2617506884 abstract "The oocyte-to-embryo transition involves extensive changes in mRNA translation, regulated in Drosophila by the PNG kinase complex whose activity we show here to be under precise developmental control. Despite presence of the catalytic PNG subunit and the PLU and GNU activating subunits in the mature oocyte, GNU is phosphorylated at Cyclin B/CDK1sites and unable to bind PNG and PLU. In vitro phosphorylation of GNU by CyclinB/CDK1 blocks activation of PNG. Meiotic completion promotes GNU dephosphorylation and PNG kinase activation to regulate translation. The critical regulatory effect of phosphorylation is shown by replacement in the oocyte with a phosphorylation-resistant form of GNU, which promotes PNG-GNU complex formation, elevation of Cyclin B, and meiotic defects consistent with premature PNG activation. After PNG activation GNU is destabilized, thus inactivating PNG. This short-lived burst in kinase activity links development with maternal mRNA translation and ensures irreversibility of the oocyte-to-embryo transition." @default.
• W2617506884 created "2017-06-05" @default.
• W2617506884 creator A5005906341 @default.
• W2617506884 creator A5034360567 @default.
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• W2617506884 date "2017-05-30" @default.
• W2617506884 modified "2023-10-09" @default.
• W2617506884 title "Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation" @default.
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• W2617506884 doi "https://doi.org/10.7554/elife.22219" @default.
• W2617506884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5449181" @default.
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• W2617506884 hasPublicationYear "2017" @default.
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