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• W2617526268 abstract "Some enzymes degrading amino acids have evolved in mammals to dampen immune responses and maintain peripheral tolerance. The enzymes metabolizing l-arginine and l-tryptophan are particularly powerful, contributing to restrain immunity towards fetal tissues and establish neonatal tolerance. Solid tumors can hijack these formidable pathways to construct a microenvironment highly unfavorable to anti-tumor T lymphocytes able to recognize them, one of mechanisms for their immune evasion. In this review, we analyze emerging concepts in the cross-talk between cells expressing these enzymes, their immune regulatory functions and pharmacological approaches that can target them to enhance cancer immunotherapy." @default.
• W2617526268 created "2017-06-05" @default.
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• W2617526268 date "2017-08-01" @default.
• W2617526268 modified "2023-10-16" @default.
• W2617526268 title "The immune regulation in cancer by the amino acid metabolizing enzymes ARG and IDO" @default.
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• W2617526268 doi "https://doi.org/10.1016/j.coph.2017.05.002" @default.
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• W2617526268 hasPublicationYear "2017" @default.
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