Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617527609> ?p ?o ?g. }
- W2617527609 abstract "Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular TGF-β signalling with idiopathic, heritable and autoimmune-associated etiologies; moreover, TGF-β blockade can prevent experimental pulmonary hypertension (PH) in pre-clinical models. TGF-β is regulated at the level of activation, but how TGF-β is activated in this disease is unknown. Here we show TGF-β activation by thrombospondin-1 (TSP-1) is both required and sufficient for the development of PH in Schistosoma-exposed mice. Following Schistosoma exposure, TSP-1 levels in the lung increase, via recruitment of circulating monocytes, while TSP-1 inhibition or knockout bone marrow prevents TGF-β activation and protects against PH development. TSP-1 blockade also prevents the PH in a second model, chronic hypoxia. Lastly, the plasma concentration of TSP-1 is significantly increased in subjects with scleroderma following PAH development. Targeting TSP-1-dependent activation of TGF-β could thus be a therapeutic approach in TGF-β-dependent vascular diseases." @default.
- W2617527609 created "2017-06-05" @default.
- W2617527609 creator A5002342890 @default.
- W2617527609 creator A5003021988 @default.
- W2617527609 creator A5003414642 @default.
- W2617527609 creator A5010401935 @default.
- W2617527609 creator A5011286329 @default.
- W2617527609 creator A5014076592 @default.
- W2617527609 creator A5015011170 @default.
- W2617527609 creator A5019306798 @default.
- W2617527609 creator A5024832487 @default.
- W2617527609 creator A5026436514 @default.
- W2617527609 creator A5031246678 @default.
- W2617527609 creator A5031600948 @default.
- W2617527609 creator A5039964177 @default.
- W2617527609 creator A5044024238 @default.
- W2617527609 creator A5044948148 @default.
- W2617527609 creator A5048551655 @default.
- W2617527609 creator A5051976264 @default.
- W2617527609 creator A5052024256 @default.
- W2617527609 creator A5054202326 @default.
- W2617527609 creator A5062555837 @default.
- W2617527609 creator A5071197863 @default.
- W2617527609 creator A5073354313 @default.
- W2617527609 creator A5074044567 @default.
- W2617527609 creator A5084888157 @default.
- W2617527609 creator A5088410041 @default.
- W2617527609 date "2017-05-30" @default.
- W2617527609 modified "2023-10-18" @default.
- W2617527609 title "TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension" @default.
- W2617527609 cites W1503388237 @default.
- W2617527609 cites W1519311536 @default.
- W2617527609 cites W1569661306 @default.
- W2617527609 cites W1573399724 @default.
- W2617527609 cites W1574865824 @default.
- W2617527609 cites W1606441445 @default.
- W2617527609 cites W165654455 @default.
- W2617527609 cites W1659420318 @default.
- W2617527609 cites W1662007645 @default.
- W2617527609 cites W1918712426 @default.
- W2617527609 cites W1921445484 @default.
- W2617527609 cites W1952271883 @default.
- W2617527609 cites W1966159197 @default.
- W2617527609 cites W1978202313 @default.
- W2617527609 cites W1981516593 @default.
- W2617527609 cites W1985595427 @default.
- W2617527609 cites W1987440087 @default.
- W2617527609 cites W1989021802 @default.
- W2617527609 cites W1989471872 @default.
- W2617527609 cites W1993679348 @default.
- W2617527609 cites W1998008605 @default.
- W2617527609 cites W2003094534 @default.
- W2617527609 cites W2007992196 @default.
- W2617527609 cites W2011671647 @default.
- W2617527609 cites W2024883161 @default.
- W2617527609 cites W2027559978 @default.
- W2617527609 cites W2028123284 @default.
- W2617527609 cites W2030576777 @default.
- W2617527609 cites W2033260397 @default.
- W2617527609 cites W2035067948 @default.
- W2617527609 cites W2038049117 @default.
- W2617527609 cites W2039863200 @default.
- W2617527609 cites W2040114855 @default.
- W2617527609 cites W2042330650 @default.
- W2617527609 cites W2042436980 @default.
- W2617527609 cites W2044609448 @default.
- W2617527609 cites W2044747531 @default.
- W2617527609 cites W2050988768 @default.
- W2617527609 cites W2053923770 @default.
- W2617527609 cites W2054226475 @default.
- W2617527609 cites W2061897796 @default.
- W2617527609 cites W2074185318 @default.
- W2617527609 cites W2085099489 @default.
- W2617527609 cites W2085675535 @default.
- W2617527609 cites W2087592423 @default.
- W2617527609 cites W2087749727 @default.
- W2617527609 cites W2088065328 @default.
- W2617527609 cites W2092032554 @default.
- W2617527609 cites W2093760093 @default.
- W2617527609 cites W2097592317 @default.
- W2617527609 cites W2101275731 @default.
- W2617527609 cites W2108723188 @default.
- W2617527609 cites W2113017194 @default.
- W2617527609 cites W2125061065 @default.
- W2617527609 cites W2129261650 @default.
- W2617527609 cites W21359101 @default.
- W2617527609 cites W2141521236 @default.
- W2617527609 cites W2152216118 @default.
- W2617527609 cites W2155049325 @default.
- W2617527609 cites W2167418026 @default.
- W2617527609 cites W2170627718 @default.
- W2617527609 cites W2171664141 @default.
- W2617527609 cites W2183644045 @default.
- W2617527609 cites W2246612893 @default.
- W2617527609 cites W2296002833 @default.
- W2617527609 cites W2399648151 @default.
- W2617527609 cites W2478548920 @default.
- W2617527609 cites W2531440323 @default.
- W2617527609 cites W2582602949 @default.
- W2617527609 cites W4231779193 @default.