FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617601840> ?p ?o ?g. }

• W2617601840 abstract "Folate receptor β (FRβ) is involved in facilitating cellular uptake of folates and anti-folates (such as methotrexate (MTX)). In rheumatoid arthritis, FRβ is expressed on synovial macrophages and recently has been explored as a biomarker for imaging in arthritic rats using the folate-based positron emission tomography (PET) tracer [18F]fluoro-PEG-folate. The purpose of this study was to examine whether this folate tracer can also be used to monitor therapeutic efficacy of MTX in arthritic rats. Arthritic rats received either no treatment or MTX therapy (1 mg/kg, either 2× or 4×). Healthy rats did not receive any arthritic induction or therapy. [18F]fluoro-PEG-folate PET-CT scans (60 min) were performed before and after MTX therapy. Following PET, the ex-vivo tissue distribution of radioactivity was determined in excised knees and multiple tissues. Synovial macrophage infiltration in knee sections was quantified by immunohistochemistry using ED1 and ED2 antibodies. PET scans clearly visualized increased uptake of [18F]fluoro-PEG-folate in arthritic knees compared with contralateral knees. Significantly lower standard uptake values (1.5-fold, p < 0.01) were observed in arthritic knees of both MTX-treated groups after therapy, approximating the levels seen in healthy rats. Consistently, ex-vivo tissue distribution demonstrated a 2–4-fold lower tracer uptake in the arthritic knee of 2× and 4× MTX-treated rats, respectively, compared with control rats. These results were corroborated with significantly reduced (2–4-fold, p < 0.01) ED1-positive and ED2-positive synovial macrophages in arthritic knees of the MTX-treated rats compared with those of the control rats. This study in arthritic rats underscores the potential and usefulness of [18F]fluoro-PEG-folate PET as a therapeutic monitoring tool of MTX therapy and potentially other anti-folate treatment of arthritis." @default.
• W2617601840 created "2017-06-05" @default.
• W2617601840 creator A5003445744 @default.
• W2617601840 creator A5007946879 @default.
• W2617601840 creator A5012446734 @default.
• W2617601840 creator A5021543324 @default.
• W2617601840 creator A5035850924 @default.
• W2617601840 creator A5063387835 @default.
• W2617601840 creator A5064656247 @default.
• W2617601840 creator A5076012975 @default.
• W2617601840 creator A5089424676 @default.
• W2617601840 creator A5090169437 @default.
• W2617601840 date "2017-05-31" @default.
• W2617601840 modified "2023-10-06" @default.
• W2617601840 title "In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography" @default.
• W2617601840 cites W129457975 @default.
• W2617601840 cites W1510770166 @default.
• W2617601840 cites W1538131630 @default.
• W2617601840 cites W1973108158 @default.
• W2617601840 cites W1979982103 @default.
• W2617601840 cites W1981775331 @default.
• W2617601840 cites W1982002204 @default.
• W2617601840 cites W1982985645 @default.
• W2617601840 cites W1988069296 @default.
• W2617601840 cites W2009193838 @default.
• W2617601840 cites W2015766239 @default.
• W2617601840 cites W2058094904 @default.
• W2617601840 cites W2060459188 @default.
• W2617601840 cites W2067848116 @default.
• W2617601840 cites W2069096810 @default.
• W2617601840 cites W2076109390 @default.
• W2617601840 cites W2083628264 @default.
• W2617601840 cites W2083793124 @default.
• W2617601840 cites W2099920614 @default.
• W2617601840 cites W2105207805 @default.
• W2617601840 cites W2112579958 @default.
• W2617601840 cites W2113542272 @default.
• W2617601840 cites W2128389838 @default.
• W2617601840 cites W2132981126 @default.
• W2617601840 cites W2148317617 @default.
• W2617601840 cites W2154389444 @default.
• W2617601840 cites W2167077543 @default.
• W2617601840 cites W2197800452 @default.
• W2617601840 cites W2266360899 @default.
• W2617601840 cites W2293327002 @default.
• W2617601840 cites W2310552124 @default.
• W2617601840 cites W2326373647 @default.
• W2617601840 cites W2328761257 @default.
• W2617601840 cites W2332873237 @default.
• W2617601840 cites W2339335481 @default.
• W2617601840 cites W2406222568 @default.
• W2617601840 cites W2410173036 @default.
• W2617601840 cites W2419626675 @default.
• W2617601840 cites W2769788832 @default.
• W2617601840 cites W4255040454 @default.
• W2617601840 cites W94987321 @default.
• W2617601840 doi "https://doi.org/10.1186/s13075-017-1325-x" @default.
• W2617601840 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5452381" @default.
• W2617601840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28569209" @default.
• W2617601840 hasPublicationYear "2017" @default.
• W2617601840 type Work @default.
• W2617601840 sameAs 2617601840 @default.
• W2617601840 citedByCount "17" @default.
• W2617601840 countsByYear W26176018402018 @default.
• W2617601840 countsByYear W26176018402020 @default.
• W2617601840 countsByYear W26176018402021 @default.
• W2617601840 countsByYear W26176018402022 @default.
• W2617601840 countsByYear W26176018402023 @default.
• W2617601840 crossrefType "journal-article" @default.
• W2617601840 hasAuthorship W2617601840A5003445744 @default.
• W2617601840 hasAuthorship W2617601840A5007946879 @default.
• W2617601840 hasAuthorship W2617601840A5012446734 @default.
• W2617601840 hasAuthorship W2617601840A5021543324 @default.
• W2617601840 hasAuthorship W2617601840A5035850924 @default.
• W2617601840 hasAuthorship W2617601840A5063387835 @default.
• W2617601840 hasAuthorship W2617601840A5064656247 @default.
• W2617601840 hasAuthorship W2617601840A5076012975 @default.
• W2617601840 hasAuthorship W2617601840A5089424676 @default.
• W2617601840 hasAuthorship W2617601840A5090169437 @default.
• W2617601840 hasBestOaLocation W26176018401 @default.
• W2617601840 hasConcept C121608353 @default.
• W2617601840 hasConcept C126322002 @default.
• W2617601840 hasConcept C142724271 @default.
• W2617601840 hasConcept C150903083 @default.
• W2617601840 hasConcept C207001950 @default.
• W2617601840 hasConcept C26291073 @default.
• W2617601840 hasConcept C2775842073 @default.
• W2617601840 hasConcept C2777077863 @default.
• W2617601840 hasConcept C2777575956 @default.
• W2617601840 hasConcept C2780306303 @default.
• W2617601840 hasConcept C2781059491 @default.
• W2617601840 hasConcept C2989005 @default.
• W2617601840 hasConcept C71924100 @default.
• W2617601840 hasConcept C86803240 @default.
• W2617601840 hasConcept C96232424 @default.
• W2617601840 hasConceptScore W2617601840C121608353 @default.
• W2617601840 hasConceptScore W2617601840C126322002 @default.
• W2617601840 hasConceptScore W2617601840C142724271 @default.
• W2617601840 hasConceptScore W2617601840C150903083 @default.
• W2617601840 hasConceptScore W2617601840C207001950 @default.

• next