FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617696856> ?p ?o ?g. }

• W2617696856 endingPage "8354" @default.
• W2617696856 startingPage "8346" @default.
• W2617696856 abstract "Cytochrome bo3 is a respiratory proton-pumping oxygen reductase that is a member of the heme-copper superfamily that utilizes ubiquinol-8 (Q8H2) as a substrate. The current consensus model has Q8H2 oxidized at a low affinity site (QL), passing electrons to a tightly bound quinone cofactor at a high affinity site (QH site) that stabilizes the one-electron reduced ubisemiquinone, facilitating the transfer of electrons to the redox active metal centers where O2 is reduced to water. The current work shows that the Q8 bound to the QH site is more dynamic than previously thought. In addition, mutations of residues at the QH site that do not abolish activity have been re-examined and shown to have properties expected of mutations at the substrate binding site (QL): an increase in the KM of the substrate ubiquinol-1 (up to 4-fold) and an increase in the apparent Ki of the inhibitor HQNO (up to 8-fold). The data suggest that there is only one binding site for ubiquinol in cyt bo3 and that site corresponds to the QH site." @default.
• W2617696856 created "2017-06-05" @default.
• W2617696856 creator A5008855880 @default.
• W2617696856 creator A5037746172 @default.
• W2617696856 creator A5040796473 @default.
• W2617696856 creator A5067485627 @default.
• W2617696856 creator A5071930198 @default.
• W2617696856 creator A5075481978 @default.
• W2617696856 date "2017-06-06" @default.
• W2617696856 modified "2023-09-26" @default.
• W2617696856 title "Location of the Substrate Binding Site of the Cytochrome <i>bo</i>₃ Ubiquinol Oxidase from <i>Escherichia coli</i>" @default.
• W2617696856 cites W1469975568 @default.
• W2617696856 cites W1523705478 @default.
• W2617696856 cites W1524183389 @default.
• W2617696856 cites W1538949060 @default.
• W2617696856 cites W1581699805 @default.
• W2617696856 cites W1594549221 @default.
• W2617696856 cites W1898563571 @default.
• W2617696856 cites W1963740551 @default.
• W2617696856 cites W1964647308 @default.
• W2617696856 cites W1965594444 @default.
• W2617696856 cites W1966286780 @default.
• W2617696856 cites W1968803666 @default.
• W2617696856 cites W1972996979 @default.
• W2617696856 cites W1980071838 @default.
• W2617696856 cites W1982722445 @default.
• W2617696856 cites W1983312132 @default.
• W2617696856 cites W1984370423 @default.
• W2617696856 cites W1988072095 @default.
• W2617696856 cites W1993487012 @default.
• W2617696856 cites W1994647784 @default.
• W2617696856 cites W2012244590 @default.
• W2617696856 cites W2019403713 @default.
• W2617696856 cites W2022439398 @default.
• W2617696856 cites W2023151223 @default.
• W2617696856 cites W2024943035 @default.
• W2617696856 cites W2031724257 @default.
• W2617696856 cites W2034430539 @default.
• W2617696856 cites W2038716844 @default.
• W2617696856 cites W2042197884 @default.
• W2617696856 cites W2047628604 @default.
• W2617696856 cites W2052721805 @default.
• W2617696856 cites W2067039368 @default.
• W2617696856 cites W2068067779 @default.
• W2617696856 cites W2070275592 @default.
• W2617696856 cites W2074088121 @default.
• W2617696856 cites W2077722456 @default.
• W2617696856 cites W2077886137 @default.
• W2617696856 cites W2079108392 @default.
• W2617696856 cites W2089675384 @default.
• W2617696856 cites W2091807016 @default.
• W2617696856 cites W2100203461 @default.
• W2617696856 cites W2105840458 @default.
• W2617696856 cites W2110176312 @default.
• W2617696856 cites W2111914500 @default.
• W2617696856 cites W2120829677 @default.
• W2617696856 cites W2124373056 @default.
• W2617696856 cites W2125061796 @default.
• W2617696856 cites W2170929465 @default.
• W2617696856 cites W2212666976 @default.
• W2617696856 cites W2328936438 @default.
• W2617696856 cites W2359350583 @default.
• W2617696856 cites W2526391010 @default.
• W2617696856 cites W2591303382 @default.
• W2617696856 cites W4211252378 @default.
• W2617696856 cites W4238652547 @default.
• W2617696856 cites W4245255344 @default.
• W2617696856 cites W963616176 @default.
• W2617696856 doi "https://doi.org/10.1021/jacs.7b03883" @default.
• W2617696856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28538096" @default.
• W2617696856 hasPublicationYear "2017" @default.
• W2617696856 type Work @default.
• W2617696856 sameAs 2617696856 @default.
• W2617696856 citedByCount "17" @default.
• W2617696856 countsByYear W26176968562018 @default.
• W2617696856 countsByYear W26176968562019 @default.
• W2617696856 countsByYear W26176968562020 @default.
• W2617696856 countsByYear W26176968562021 @default.
• W2617696856 crossrefType "journal-article" @default.
• W2617696856 hasAuthorship W2617696856A5008855880 @default.
• W2617696856 hasAuthorship W2617696856A5037746172 @default.
• W2617696856 hasAuthorship W2617696856A5040796473 @default.
• W2617696856 hasAuthorship W2617696856A5067485627 @default.
• W2617696856 hasAuthorship W2617696856A5071930198 @default.
• W2617696856 hasAuthorship W2617696856A5075481978 @default.
• W2617696856 hasConcept C107824862 @default.
• W2617696856 hasConcept C111368507 @default.
• W2617696856 hasConcept C123669783 @default.
• W2617696856 hasConcept C127313418 @default.
• W2617696856 hasConcept C14471203 @default.
• W2617696856 hasConcept C181199279 @default.
• W2617696856 hasConcept C185592680 @default.
• W2617696856 hasConcept C2777289219 @default.
• W2617696856 hasConcept C2778777121 @default.
• W2617696856 hasConcept C2780768313 @default.
• W2617696856 hasConcept C28859421 @default.
• W2617696856 hasConcept C29311851 @default.
• W2617696856 hasConcept C41183919 @default.

• next