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- W2617698876 abstract "Following the discovery of the mitochondria-associated membrane (MAM) as a hub for lipid metabolism in 1990 and its description as one of the first examples for membrane contact sites (MCS) at the turn of the century, the past decade has seen the emergence of this structure as a potential regulator of cancer growth and metabolism. The mechanistic basis for this hypothesis is that the MAM accommodates flux of Ca2+ from the endoplasmic reticulum (ER) to mitochondria. This flux then determines mitochondrial ATP production, known to be low in many tumors as part of the Warburg effect. However, low mitochondrial Ca2+ flux also reduces the propensity of tumor cells to undergo apoptosis, another cancer hallmark. Numerous regulators of this flux have been recently identified as MAM proteins. Not surprisingly, many fall into the groups of tumor suppressors and oncogenes. Given the important role that the MAM could play in cancer, it is expected that proteins mediating its formation are particularly implicated in tumorigenesis. Examples for such proteins are mitofusin-2 and phosphofurin acidic cluster sorting protein 2 (PACS-2) that likely act as tumor suppressors. This review discusses how these proteins that mediate or regulate ER-mitochondria tethering are (or are not) promoting or inhibiting tumorigenesis. The emerging picture of MAMs in cancer seems to indicate that in addition to the downregulation of mitochondrial Ca2+ import, MAM defects are but one way how cancer cells control mitochondria metabolism and apoptosis." @default.
- W2617698876 created "2017-06-05" @default.
- W2617698876 creator A5005161224 @default.
- W2617698876 creator A5022362508 @default.
- W2617698876 date "2017-05-26" @default.
- W2617698876 modified "2023-10-18" @default.
- W2617698876 title "Cancer: Untethering Mitochondria from the Endoplasmic Reticulum?" @default.
- W2617698876 cites W1243294255 @default.
- W2617698876 cites W1490486327 @default.
- W2617698876 cites W1494153437 @default.
- W2617698876 cites W1495618127 @default.
- W2617698876 cites W1513631124 @default.
- W2617698876 cites W1528834211 @default.
- W2617698876 cites W1532297263 @default.
- W2617698876 cites W1591934633 @default.
- W2617698876 cites W1600166291 @default.
- W2617698876 cites W1669771493 @default.
- W2617698876 cites W1757875555 @default.
- W2617698876 cites W1802480460 @default.
- W2617698876 cites W1826908572 @default.
- W2617698876 cites W1892275027 @default.
- W2617698876 cites W1918420563 @default.
- W2617698876 cites W1963686368 @default.
- W2617698876 cites W1963874479 @default.
- W2617698876 cites W1967184808 @default.
- W2617698876 cites W1967203467 @default.
- W2617698876 cites W1967291345 @default.
- W2617698876 cites W1970420856 @default.
- W2617698876 cites W1970990976 @default.
- W2617698876 cites W1971355336 @default.
- W2617698876 cites W1972505801 @default.
- W2617698876 cites W1972621040 @default.
- W2617698876 cites W1974878211 @default.
- W2617698876 cites W1975286848 @default.
- W2617698876 cites W1976943917 @default.
- W2617698876 cites W1980804643 @default.
- W2617698876 cites W1981762416 @default.
- W2617698876 cites W1989397745 @default.
- W2617698876 cites W1989637780 @default.
- W2617698876 cites W1991959810 @default.
- W2617698876 cites W1993418135 @default.
- W2617698876 cites W1997527771 @default.
- W2617698876 cites W2000115025 @default.
- W2617698876 cites W2000960994 @default.
- W2617698876 cites W2001389093 @default.
- W2617698876 cites W2001796296 @default.
- W2617698876 cites W2002057703 @default.
- W2617698876 cites W2003416462 @default.
- W2617698876 cites W2004897979 @default.
- W2617698876 cites W2005216847 @default.
- W2617698876 cites W2010083809 @default.
- W2617698876 cites W2012325856 @default.
- W2617698876 cites W2014349355 @default.
- W2617698876 cites W2016671984 @default.
- W2617698876 cites W2019221181 @default.
- W2617698876 cites W2019759067 @default.
- W2617698876 cites W2021181403 @default.
- W2617698876 cites W2021592710 @default.
- W2617698876 cites W2022169605 @default.
- W2617698876 cites W2026967508 @default.
- W2617698876 cites W2027705428 @default.
- W2617698876 cites W2028635837 @default.
- W2617698876 cites W2028974980 @default.
- W2617698876 cites W2033958147 @default.
- W2617698876 cites W2035759514 @default.
- W2617698876 cites W2035944529 @default.
- W2617698876 cites W2037908592 @default.
- W2617698876 cites W2041608387 @default.
- W2617698876 cites W2042224403 @default.
- W2617698876 cites W2043091620 @default.
- W2617698876 cites W2043850619 @default.
- W2617698876 cites W2044375122 @default.
- W2617698876 cites W2047195788 @default.
- W2617698876 cites W2049568685 @default.
- W2617698876 cites W2052622892 @default.
- W2617698876 cites W2052737683 @default.
- W2617698876 cites W2054257071 @default.
- W2617698876 cites W2055309496 @default.
- W2617698876 cites W2056950685 @default.
- W2617698876 cites W2057002873 @default.
- W2617698876 cites W2057559671 @default.
- W2617698876 cites W2062535484 @default.
- W2617698876 cites W2065102742 @default.
- W2617698876 cites W2066088939 @default.
- W2617698876 cites W2067790100 @default.
- W2617698876 cites W2072451938 @default.
- W2617698876 cites W2072939418 @default.
- W2617698876 cites W2074171009 @default.
- W2617698876 cites W2076386951 @default.
- W2617698876 cites W2078824404 @default.
- W2617698876 cites W2085331940 @default.
- W2617698876 cites W2087493485 @default.
- W2617698876 cites W2088053459 @default.
- W2617698876 cites W2090214297 @default.
- W2617698876 cites W2090626599 @default.
- W2617698876 cites W2091552622 @default.
- W2617698876 cites W2092087129 @default.
- W2617698876 cites W2095987251 @default.
- W2617698876 cites W2096579721 @default.
- W2617698876 cites W2096852894 @default.