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• W2617720609 abstract "Summary The addition of excess thymidine (5 × 10-3m) to Novikoff tissue culture cells growing in suspension produced the following results: (a) cell multiplication, deoxyribonucleic acid (DNA) synthesis, and, to a less extent, ribonucleic acid (RNA) synthesis were depressed; (b) the uptake, and incorporation into DNA, of tritiated deoxycytidine were stimulated; and (c) the uptake, and incorporation into both RNA and DNA, of tritiated cytidine were depressed markedly. When cells previously adapted to growth in excess thymidine were used, the above effects were greatly reduced, with the exception of the utilization of tritiated cytidine, which remained depressed. The stimulated utilization of tritiated deoxycytidine, which is most pronounced in those cell lines in which multiplication is inhibited by thymidine, apparently results primarily from a requirement for exogenous deoxycytidine induced by feedback inhibition by thymidine triphosphate of the production of deoxycytidine nucleotides." @default.
• W2617720609 created "2017-06-05" @default.
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• W2617720609 date "1965-05-01" @default.
• W2617720609 modified "2023-09-23" @default.
• W2617720609 title "PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. 3. RELATIONSHIP OF THYMIDINE TO THE METABOLISM OF OTHER PYRIMIDINE NUCLEOSIDES IN SUSPENSION CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA." @default.
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