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• W2617761485 abstract "Angiogenesis provides nutrients and oxygen to promote tumor growth and affords a channel that facilitates tumor cell entry into the circulation. Andrographolide (Andro) possess anti-tumor activity; however, its direct effect on angiogenesis still needs to be clarified. In this study, our experiments revealed that Andro significantly inhibited vascular growth in chick embryo chorioallantoic membrane (CAM) and yolk sac membrane (YSM) models. Meanwhile, tumor angiogenesis was also suppressed by Andro. Additionally, we found that cell proliferation, migration and tube formation of vascular endothelial cells was inhibited by Andro treatment in vitro. The effect was primarily mediated through inhibition of miR-21-5p expression and further targeting of TIMP3. This work provides evidence that Andro directly inhibits angiogenesis and might be an effective anti-angiogenic therapeutic drug for cancer treatment." @default.
• W2617761485 created "2017-06-05" @default.
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• W2617761485 date "2017-01-01" @default.
• W2617761485 modified "2023-10-05" @default.
• W2617761485 title "Andrographolide Inhibits Angiogenesis by Inhibiting the Mir-21-5p/TIMP3 Signaling Pathway" @default.
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• W2617761485 doi "https://doi.org/10.7150/ijbs.19194" @default.
• W2617761485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5441182" @default.
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