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- W2617851180 abstract "620 Objectives Multispectral optoacoustic tomography (MSOT) was used to track injected monocytes, labeled with an NIR chromophore, in a model of dss-induced colitis. Monocyte distribution in lymphoid organs and chronic sites of inflammation within the gut were monitored over a 48 hour period. The functional response to an injection of a vascular disrupting agent was also assessed in a HT1090 fibrosarcoma. Methods Multispectral Optoacoustic Imaging (MSOT) is an emerging modality that combines ultrasound resolution (150 µm) and short acquisition times (µs) with optical contrast in the near infrared spectral region. MSOT allows the localization of injected targeted fluorophores with NIR absorbance to offer molecular contrast, while visualization of endogenous contrast such as deoxy-/oxy-hemoglobin offers both functional and anatomical information. Results Whole body imaging shows monocyte distribution throughout the abdominal region of each mouse. A peak MSOT signal from labelled monocytes was observed at 24 hours after dss-induction. Truncated tissue factor (tTF) fused to an NGR-peptide (tTF-NGR) targets CD13, which is overexpressed in tumor endothelial cells. After binding, it is known to cause vascular disruption, blood pooling and vessel occlusions within the tumor vasculature. These processes were associated with an increase in MSOT-associated deoxyhemoblin signal in the tumor. Conclusions MSOT offers an imaging modality that can provide anatomical, functional, molecular and kinetic information at high temporal and spatial resolution. When combined with (molecular) imaging agents that possess appropriate targeting properties, this modality can be leveraged for new biomarker imaging approaches in cancer research." @default.
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- W2617851180 date "2015-05-01" @default.
- W2617851180 modified "2023-09-23" @default.
- W2617851180 title "Dynamic imaging of chronic inflammation and tumour therapeutic response with multispectral optoacoustic tomography (MSOT) ." @default.
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