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- W2617870290 abstract "e13503 Background: Diffuse optical imaging techniques for measuring tissue hemoglobin concentration have been recently accepted as a way to assess tumor vascularity and oxygenation. We investigated the correlation between early optical response to single-agent bevacizumab and treatment outcome. Methods: Seven patients with advanced or metastatic breast cancer were treated with single-agent bevacizumab followed by addition of weekly paclitaxel. Optical imaging of patient’s breasts was performed to measure tumor total hemoglobin concentration (tHb) and oxygen saturation (stO2) at baseline and on days 1, 3, 6, 8, and 13 after the first infusion of bevacizumab. To assess early metabolic response, 2-deoxy-2-(18F)-fluoro-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT), 18F-fluoromisonidazole (FMISO)-PET/CT, and magnetic resonance imaging were performed at baseline and after two cycles of the regimen. Results: Seven patients were grouped as responders (n = 4) and nonresponders (n = 3) o..." @default.
- W2617870290 created "2017-06-05" @default.
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- W2617870290 date "2014-05-20" @default.
- W2617870290 modified "2023-09-27" @default.
- W2617870290 title "Optical imaging for monitoring tumor oxygenation response after initiation of single-agent bevacizumab followed by neoadjuvant chemotherapy in breast cancer patients." @default.
- W2617870290 doi "https://doi.org/10.1200/jco.2014.32.15_suppl.e13503" @default.
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