Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617946428> ?p ?o ?g. }
- W2617946428 abstract "Since 2009, evidence has accumulated to suggest that Tau aggregates form first in a small number of brain cells, from where they propagate to other regions, resulting in neurodegeneration and disease. Propagation of Tau aggregates is often called prion-like, which refers to the capacity of an assembled protein to induce the same abnormal conformation in a protein of the same kind, initiating a self-amplifying cascade. In addition, prion-like encompasses the release of protein aggregates from brain cells and their uptake by neighbouring cells. In mice, the intracerebral injection of Tau inclusions induced the ordered assembly of monomeric Tau, followed by its spreading to distant brain regions. Short fibrils constituted the major species of seed-competent Tau. The existence of several human Tauopathies with distinct fibril morphologies has led to the suggestion that different molecular conformers (or strains) of aggregated Tau exist." @default.
- W2617946428 created "2017-06-05" @default.
- W2617946428 creator A5037379608 @default.
- W2617946428 creator A5037609259 @default.
- W2617946428 date "2017-05-30" @default.
- W2617946428 modified "2023-10-09" @default.
- W2617946428 title "Propagation of Tau aggregates" @default.
- W2617946428 cites W1032333588 @default.
- W2617946428 cites W1509571186 @default.
- W2617946428 cites W1511517753 @default.
- W2617946428 cites W1568040350 @default.
- W2617946428 cites W1569576869 @default.
- W2617946428 cites W1764460837 @default.
- W2617946428 cites W1830376997 @default.
- W2617946428 cites W1878810938 @default.
- W2617946428 cites W1897859562 @default.
- W2617946428 cites W1918417411 @default.
- W2617946428 cites W1967285029 @default.
- W2617946428 cites W1971032265 @default.
- W2617946428 cites W1974760231 @default.
- W2617946428 cites W1989208474 @default.
- W2617946428 cites W1994282166 @default.
- W2617946428 cites W2002149890 @default.
- W2617946428 cites W2007871841 @default.
- W2617946428 cites W2011200428 @default.
- W2617946428 cites W2013679718 @default.
- W2617946428 cites W2016479797 @default.
- W2617946428 cites W2018908557 @default.
- W2617946428 cites W2025468199 @default.
- W2617946428 cites W2028410287 @default.
- W2617946428 cites W2032221178 @default.
- W2617946428 cites W2033672635 @default.
- W2617946428 cites W2036362108 @default.
- W2617946428 cites W2043111202 @default.
- W2617946428 cites W2045220210 @default.
- W2617946428 cites W2050252352 @default.
- W2617946428 cites W2051896853 @default.
- W2617946428 cites W2054922779 @default.
- W2617946428 cites W2057682957 @default.
- W2617946428 cites W2059809766 @default.
- W2617946428 cites W2060004104 @default.
- W2617946428 cites W2071921522 @default.
- W2617946428 cites W2072372569 @default.
- W2617946428 cites W2074274706 @default.
- W2617946428 cites W2081431264 @default.
- W2617946428 cites W2081966615 @default.
- W2617946428 cites W2089331767 @default.
- W2617946428 cites W2089607910 @default.
- W2617946428 cites W2091305524 @default.
- W2617946428 cites W2096321704 @default.
- W2617946428 cites W2097717784 @default.
- W2617946428 cites W2098187463 @default.
- W2617946428 cites W2099340107 @default.
- W2617946428 cites W2108044151 @default.
- W2617946428 cites W2113529979 @default.
- W2617946428 cites W2116508134 @default.
- W2617946428 cites W2117537971 @default.
- W2617946428 cites W2124019813 @default.
- W2617946428 cites W2124317694 @default.
- W2617946428 cites W2126128897 @default.
- W2617946428 cites W2133379491 @default.
- W2617946428 cites W2140631432 @default.
- W2617946428 cites W2141839336 @default.
- W2617946428 cites W2142366168 @default.
- W2617946428 cites W2142980305 @default.
- W2617946428 cites W2147718170 @default.
- W2617946428 cites W2153323361 @default.
- W2617946428 cites W2159377066 @default.
- W2617946428 cites W2161001592 @default.
- W2617946428 cites W2172007938 @default.
- W2617946428 cites W2189621653 @default.
- W2617946428 cites W2190404250 @default.
- W2617946428 cites W2317760348 @default.
- W2617946428 cites W2327550735 @default.
- W2617946428 cites W2329336071 @default.
- W2617946428 cites W2412227163 @default.
- W2617946428 cites W2472346278 @default.
- W2617946428 cites W2482025842 @default.
- W2617946428 cites W2505710738 @default.
- W2617946428 cites W2507989145 @default.
- W2617946428 cites W2519516239 @default.
- W2617946428 cites W2534587007 @default.
- W2617946428 cites W2545421204 @default.
- W2617946428 cites W2551607099 @default.
- W2617946428 cites W2557275668 @default.
- W2617946428 cites W2582711285 @default.
- W2617946428 cites W2618553145 @default.
- W2617946428 doi "https://doi.org/10.1186/s13041-017-0298-7" @default.
- W2617946428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5450399" @default.
- W2617946428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28558799" @default.
- W2617946428 hasPublicationYear "2017" @default.
- W2617946428 type Work @default.
- W2617946428 sameAs 2617946428 @default.
- W2617946428 citedByCount "142" @default.
- W2617946428 countsByYear W26179464282017 @default.
- W2617946428 countsByYear W26179464282018 @default.
- W2617946428 countsByYear W26179464282019 @default.
- W2617946428 countsByYear W26179464282020 @default.
- W2617946428 countsByYear W26179464282021 @default.
- W2617946428 countsByYear W26179464282022 @default.