FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617961010> ?p ?o ?g. }

• W2617961010 abstract "Abstract Although the diagnosis of Parkinson’s disease (PD) remains anchored around the cardinal motor symptoms of bradykinesia, rest tremor, rigidity and postural instability, it is becoming increasingly clear that the clinical phase of the disease is preceded by a long period of neurodegeneration, which is not readily evident in terms of motor dysfunction. The neurobiological mechanisms that underpin this prodromal phase of PD remain poorly understood. Based on converging evidence of basal ganglia (BG) dysfunction in early PD, we set out to establish whether the prodromal phase of the disease is characterized by alterations in functional communication within the input and output structures of the BG. We analyzed resting-state functional MRI data collected from patients with REM sleep behavior disorder (RBD) and/or hyposmia, two of the strongest markers of prodromal PD, in comparison to age-matched controls. Relative to controls, subjects in the prodromal group showed reduced intra- and interhemispheric functional connectivity in a striato-thalamo-pallidal network. Functional connectivity alterations were restricted to the BG and did not extend to functional connections with the cortex. The data suggest that local interactions between input and output BG structures may be disrupted already in the prodromal phase of PD." @default.
• W2617961010 created "2017-06-05" @default.
• W2617961010 creator A5023779111 @default.
• W2617961010 creator A5084142815 @default.
• W2617961010 date "2017-05-22" @default.
• W2617961010 modified "2023-09-28" @default.
• W2617961010 title "Alterations in striato-thalamo-pallidal intrinsic functional connectivity as a prodrome of Parkinson’s disease" @default.
• W2617961010 cites W1920030402 @default.
• W2617961010 cites W1983183519 @default.
• W2617961010 cites W1988494453 @default.
• W2617961010 cites W1989165123 @default.
• W2617961010 cites W1990134753 @default.
• W2617961010 cites W1992104307 @default.
• W2617961010 cites W2001381028 @default.
• W2617961010 cites W2012769853 @default.
• W2617961010 cites W2016696802 @default.
• W2617961010 cites W2017997582 @default.
• W2617961010 cites W2019450648 @default.
• W2617961010 cites W2020101887 @default.
• W2617961010 cites W2035819830 @default.
• W2617961010 cites W2035972257 @default.
• W2617961010 cites W2063497316 @default.
• W2617961010 cites W2073449985 @default.
• W2617961010 cites W2103226055 @default.
• W2617961010 cites W2106704612 @default.
• W2617961010 cites W2112455323 @default.
• W2617961010 cites W2121300131 @default.
• W2617961010 cites W2126838454 @default.
• W2617961010 cites W2134155886 @default.
• W2617961010 cites W2165758561 @default.
• W2617961010 cites W2179197468 @default.
• W2617961010 cites W2200784452 @default.
• W2617961010 cites W2299466991 @default.
• W2617961010 cites W2421214640 @default.
• W2617961010 cites W2464433823 @default.
• W2617961010 cites W2539957110 @default.
• W2617961010 cites W2554537093 @default.
• W2617961010 cites W2559687221 @default.
• W2617961010 cites W2587446674 @default.
• W2617961010 cites W2605144672 @default.
• W2617961010 doi "https://doi.org/10.1101/140830" @default.
• W2617961010 hasPublicationYear "2017" @default.
• W2617961010 type Work @default.
• W2617961010 sameAs 2617961010 @default.
• W2617961010 citedByCount "0" @default.
• W2617961010 crossrefType "posted-content" @default.
• W2617961010 hasAuthorship W2617961010A5023779111 @default.
• W2617961010 hasAuthorship W2617961010A5084142815 @default.
• W2617961010 hasBestOaLocation W26179610101 @default.
• W2617961010 hasConcept C118552586 @default.
• W2617961010 hasConcept C126322002 @default.
• W2617961010 hasConcept C15744967 @default.
• W2617961010 hasConcept C169760540 @default.
• W2617961010 hasConcept C2776925932 @default.
• W2617961010 hasConcept C2778187257 @default.
• W2617961010 hasConcept C2779134260 @default.
• W2617961010 hasConcept C2779714222 @default.
• W2617961010 hasConcept C2779727114 @default.
• W2617961010 hasConcept C2779734285 @default.
• W2617961010 hasConcept C2780292510 @default.
• W2617961010 hasConcept C2780647506 @default.
• W2617961010 hasConcept C529278444 @default.
• W2617961010 hasConcept C71924100 @default.
• W2617961010 hasConceptScore W2617961010C118552586 @default.
• W2617961010 hasConceptScore W2617961010C126322002 @default.
• W2617961010 hasConceptScore W2617961010C15744967 @default.
• W2617961010 hasConceptScore W2617961010C169760540 @default.
• W2617961010 hasConceptScore W2617961010C2776925932 @default.
• W2617961010 hasConceptScore W2617961010C2778187257 @default.
• W2617961010 hasConceptScore W2617961010C2779134260 @default.
• W2617961010 hasConceptScore W2617961010C2779714222 @default.
• W2617961010 hasConceptScore W2617961010C2779727114 @default.
• W2617961010 hasConceptScore W2617961010C2779734285 @default.
• W2617961010 hasConceptScore W2617961010C2780292510 @default.
• W2617961010 hasConceptScore W2617961010C2780647506 @default.
• W2617961010 hasConceptScore W2617961010C529278444 @default.
• W2617961010 hasConceptScore W2617961010C71924100 @default.
• W2617961010 hasLocation W26179610101 @default.
• W2617961010 hasLocation W26179610102 @default.
• W2617961010 hasLocation W26179610103 @default.
• W2617961010 hasOpenAccess W2617961010 @default.
• W2617961010 hasPrimaryLocation W26179610101 @default.
• W2617961010 hasRelatedWork W1467542484 @default.
• W2617961010 hasRelatedWork W1560595356 @default.
• W2617961010 hasRelatedWork W1856865312 @default.
• W2617961010 hasRelatedWork W2027712101 @default.
• W2617961010 hasRelatedWork W2035819830 @default.
• W2617961010 hasRelatedWork W2076158082 @default.
• W2617961010 hasRelatedWork W2125285219 @default.
• W2617961010 hasRelatedWork W2263207417 @default.
• W2617961010 hasRelatedWork W2594587565 @default.
• W2617961010 hasRelatedWork W2647803208 @default.
• W2617961010 hasRelatedWork W2751250516 @default.
• W2617961010 hasRelatedWork W2767043993 @default.
• W2617961010 hasRelatedWork W2801998586 @default.
• W2617961010 hasRelatedWork W2897499013 @default.
• W2617961010 hasRelatedWork W2951011126 @default.
• W2617961010 hasRelatedWork W2997807571 @default.
• W2617961010 hasRelatedWork W3024329508 @default.
• W2617961010 hasRelatedWork W3082300972 @default.

• next