FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2617961063> ?p ?o ?g. }

• W2617961063 endingPage "740" @default.
• W2617961063 startingPage "729" @default.
• W2617961063 abstract "UPEC is the main cause of urinary tract infections. Integrated multi-omic analyses promise to provide deep insights into UPEC biology. Next-generation sequencing has enabled rapid low-cost sequencing of whole genomes, to explore the diversity of UPEC strains. The UPEC pan genome remains open, highlighting the complexity of this pathogen. Transcriptomics has identified key UPEC genes transcribed during different conditions, including laboratory growth, experimental UTI, and human UTI. Advances in mass spectrometry (MS) enable global proteome analysis. Matrix-assisted laser desorption/ionization (MALDI) imaging can be applied to dissect the spatial organization of UPEC biofilms. Surface or secreted proteins are likely to be high-value targets for identifying vaccine candidates, proteins involved in binding to host cells, and drug targets. Uropathogenic Escherichia coli (UPEC) is a pathogen of major significance to global human health and is strongly associated with rapidly increasing antibiotic resistance. UPEC is the primary cause of urinary tract infection (UTI), a disease that involves a complicated pathogenic pathway of extracellular and intracellular lifestyles during interaction with the host. The application of multiple ‘omic’ technologies, including genomics, transcriptomics, proteomics, and metabolomics, has provided enormous knowledge to our understanding of UPEC biology. Here we outline this progress and present a view for future developments using these exciting forefront technologies to fully comprehend UPEC pathogenesis in the context of infection. Uropathogenic Escherichia coli (UPEC) is a pathogen of major significance to global human health and is strongly associated with rapidly increasing antibiotic resistance. UPEC is the primary cause of urinary tract infection (UTI), a disease that involves a complicated pathogenic pathway of extracellular and intracellular lifestyles during interaction with the host. The application of multiple ‘omic’ technologies, including genomics, transcriptomics, proteomics, and metabolomics, has provided enormous knowledge to our understanding of UPEC biology. Here we outline this progress and present a view for future developments using these exciting forefront technologies to fully comprehend UPEC pathogenesis in the context of infection. is the global study of pathways and networks of cellular lipids in biological systems. is an analytic technique that incorporates the tandem use of physical separation capability of LC with the mass measuring capability of MS. MS/MS is a combination of two mass spectrometers in tandem to improve sensitivity and to gain more structural information of the analyte studied based on fragmentation patterns. is a tool that allows soft ionization of biomolecules mixed with an organic compound matrix by laser beam with minimal fragmentation of samples. The resulting protonated ions are then accelerated using an electric charge, and the time of flight to reach to a detector is measured. A characteristic spectrum is generated for the analytes in each sample and compared to publicly available databases for identification. allows for two-dimensional in situ measurement of the relative abundance and spatial distribution of proteins and small molecules within biological systems whilst maintaining their cellular and molecular integrity. is the global identification and quantification of small metabolites associated with metabolic pathways of biological systems. is a method that takes advantage of genome sequences for the identification of putative vaccine antigens. Using bioinformatics prediction tools, potential surface-exposed or secreted proteins can be identified and then tested for their immunogenicity and protective efficacy in animal infection models. is a tool for capturing snapshots of the global cellular transcriptome change at a given time point and condition. RNA is converted to cDNA and used as input to a next-generation sequencing library preparation. RNA-seq enables identification and quantitation of mRNA and other RNA species. is a data-independent acquisition technique that systematically performs MS/MS, generating a comprehensive record of fragmentation ion spectra of all analytes and enabling unbiased identification and quantitation of relative protein abundance." @default.
• W2617961063 created "2017-06-05" @default.
• W2617961063 creator A5004563487 @default.
• W2617961063 creator A5014953176 @default.
• W2617961063 creator A5039569828 @default.
• W2617961063 creator A5059456421 @default.
• W2617961063 creator A5080285308 @default.
• W2617961063 creator A5080392287 @default.
• W2617961063 creator A5087445309 @default.
• W2617961063 date "2017-09-01" @default.
• W2617961063 modified "2023-10-02" @default.
• W2617961063 title "‘Omic’ Approaches to Study Uropathogenic Escherichia coli Virulence" @default.
• W2617961063 cites W1509804011 @default.
• W2617961063 cites W1902622715 @default.
• W2617961063 cites W1917629533 @default.
• W2617961063 cites W1920720327 @default.
• W2617961063 cites W1938844568 @default.
• W2617961063 cites W1941154453 @default.
• W2617961063 cites W1971403296 @default.
• W2617961063 cites W1972223538 @default.
• W2617961063 cites W1977021189 @default.
• W2617961063 cites W1983159191 @default.
• W2617961063 cites W1984708728 @default.
• W2617961063 cites W1986815313 @default.
• W2617961063 cites W1994170056 @default.
• W2617961063 cites W1996387484 @default.
• W2617961063 cites W1999823179 @default.
• W2617961063 cites W2000964393 @default.
• W2617961063 cites W2002232188 @default.
• W2617961063 cites W2009181053 @default.
• W2617961063 cites W2010458009 @default.
• W2617961063 cites W2014008119 @default.
• W2617961063 cites W2014151922 @default.
• W2617961063 cites W2016309466 @default.
• W2617961063 cites W2016411536 @default.
• W2617961063 cites W2023956150 @default.
• W2617961063 cites W2029848310 @default.
• W2617961063 cites W2031240692 @default.
• W2617961063 cites W2032331568 @default.
• W2617961063 cites W2039204405 @default.
• W2617961063 cites W2045552068 @default.
• W2617961063 cites W2047353791 @default.
• W2617961063 cites W2048773502 @default.
• W2617961063 cites W2052484895 @default.
• W2617961063 cites W2057587367 @default.
• W2617961063 cites W2059801322 @default.
• W2617961063 cites W2060842569 @default.
• W2617961063 cites W2060993546 @default.
• W2617961063 cites W2065213868 @default.
• W2617961063 cites W2065968048 @default.
• W2617961063 cites W2066107696 @default.
• W2617961063 cites W2067663293 @default.
• W2617961063 cites W2070063001 @default.
• W2617961063 cites W2070920909 @default.
• W2617961063 cites W2073432990 @default.
• W2617961063 cites W2079192886 @default.
• W2617961063 cites W2079843936 @default.
• W2617961063 cites W2081697692 @default.
• W2617961063 cites W2083275944 @default.
• W2617961063 cites W2084821192 @default.
• W2617961063 cites W2087606064 @default.
• W2617961063 cites W2098716491 @default.
• W2617961063 cites W2103517094 @default.
• W2617961063 cites W2109499778 @default.
• W2617961063 cites W2115978114 @default.
• W2617961063 cites W2120391797 @default.
• W2617961063 cites W2123022837 @default.
• W2617961063 cites W2127789620 @default.
• W2617961063 cites W2128569683 @default.
• W2617961063 cites W2129742068 @default.
• W2617961063 cites W2129754475 @default.
• W2617961063 cites W2132682438 @default.
• W2617961063 cites W2133937691 @default.
• W2617961063 cites W2136296923 @default.
• W2617961063 cites W2136361919 @default.
• W2617961063 cites W2136946610 @default.
• W2617961063 cites W2141292721 @default.
• W2617961063 cites W2144148663 @default.
• W2617961063 cites W2151349229 @default.
• W2617961063 cites W2151645494 @default.
• W2617961063 cites W2152045787 @default.
• W2617961063 cites W2153139855 @default.
• W2617961063 cites W2154070326 @default.
• W2617961063 cites W2154075906 @default.
• W2617961063 cites W2157612734 @default.
• W2617961063 cites W2158990411 @default.
• W2617961063 cites W2160240386 @default.
• W2617961063 cites W2160545383 @default.
• W2617961063 cites W2161194601 @default.
• W2617961063 cites W2163186898 @default.
• W2617961063 cites W2169342629 @default.
• W2617961063 cites W2174743278 @default.
• W2617961063 cites W2177029917 @default.
• W2617961063 cites W2191824721 @default.
• W2617961063 cites W2229751746 @default.
• W2617961063 cites W2294658832 @default.
• W2617961063 cites W2301767426 @default.
• W2617961063 cites W2311395181 @default.

• next