FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2618105171> ?p ?o ?g. }

• W2618105171 endingPage "554" @default.
• W2618105171 startingPage "554" @default.
• W2618105171 abstract "Annual wormwood (AW) (Artemisia annua L.) has anti-malarial, anti-bacterial, anti-oxidant, anti-tumour, and anti-inflammatory activities. In the present study, we evaluated the effects of annual wormwood leaves (AWL) on adipocyte differentiation in 3T3-L1 cells and high-fat diet (HFD)-induced obese rats. 3T3-L1 adipocytes and HFD-induced obese rats were treated with AWL, and its effect on gene expression was analyzed using RT-PCR and Western blotting experiments. Treatment with AWL effectively prevented triglyceride accumulation during adipogenesis in a dose-dependent manner. Consistently, AWL suppressed the differentiation of 3T3-L1 preadipocytes into adipocytes through the downregulation of dexamethasone, 3-isobutyl-1- methylxanthine, and insulin (DMI)-induced serine/threonine kinase protein kinase B (PKB/Akt) activation and the expression of adipogenic genes, including the CCAAT/enhancer binding protein-α (C/EBPα) and peroximal proliferator-activated receptor-γ (PPARγ). Moreover, the expression of adipocyte fatty acid-binding protein 4 (aP2), which is a known PPARγ-target gene, was downregulated by AWL treatment. Oral administration of AWL extracts significantly decreased the body weight gain, adipose tissue mass, adipocyte cell size, serum triglyceride (TG), and total cholesterol (TC) levels in HFD-induced obese rats. These results provide novel insight into the molecular mechanisms underlying the anti-obesity effects of AWL that are mediated by the downregulation of the expression of major adipogenic transcription factors, C/EBPα and PPARγ and Akt signalling." @default.
• W2618105171 created "2017-06-05" @default.
• W2618105171 creator A5005659473 @default.
• W2618105171 creator A5013643055 @default.
• W2618105171 creator A5015583817 @default.
• W2618105171 creator A5038370010 @default.
• W2618105171 creator A5041455638 @default.
• W2618105171 creator A5043310912 @default.
• W2618105171 creator A5063862119 @default.
• W2618105171 creator A5091010178 @default.
• W2618105171 date "2017-05-28" @default.
• W2618105171 modified "2023-09-27" @default.
• W2618105171 title "Annual Wormwood Leaf Inhibits the Adipogenesis of 3T3-L1 and Obesity in High-Fat Diet-Induced Obese Rats" @default.
• W2618105171 cites W1907219612 @default.
• W2618105171 cites W1921328412 @default.
• W2618105171 cites W1970439560 @default.
• W2618105171 cites W1977241157 @default.
• W2618105171 cites W1989294105 @default.
• W2618105171 cites W2013299486 @default.
• W2618105171 cites W2028765375 @default.
• W2618105171 cites W2033204507 @default.
• W2618105171 cites W2033992955 @default.
• W2618105171 cites W2037941417 @default.
• W2618105171 cites W2052045899 @default.
• W2618105171 cites W2052609811 @default.
• W2618105171 cites W2052827925 @default.
• W2618105171 cites W2057114766 @default.
• W2618105171 cites W2058138221 @default.
• W2618105171 cites W2059992589 @default.
• W2618105171 cites W2062051365 @default.
• W2618105171 cites W2075097891 @default.
• W2618105171 cites W2087390102 @default.
• W2618105171 cites W2088475360 @default.
• W2618105171 cites W2088659261 @default.
• W2618105171 cites W2091177188 @default.
• W2618105171 cites W2095518262 @default.
• W2618105171 cites W2102313291 @default.
• W2618105171 cites W2115801388 @default.
• W2618105171 cites W2124359549 @default.
• W2618105171 cites W2133470303 @default.
• W2618105171 cites W2137563421 @default.
• W2618105171 cites W2284659436 @default.
• W2618105171 cites W2470134334 @default.
• W2618105171 cites W4237205057 @default.
• W2618105171 doi "https://doi.org/10.3390/nu9060554" @default.
• W2618105171 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5490533" @default.
• W2618105171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28555033" @default.
• W2618105171 hasPublicationYear "2017" @default.
• W2618105171 type Work @default.
• W2618105171 sameAs 2618105171 @default.
• W2618105171 citedByCount "17" @default.
• W2618105171 countsByYear W26181051712017 @default.
• W2618105171 countsByYear W26181051712018 @default.
• W2618105171 countsByYear W26181051712019 @default.
• W2618105171 countsByYear W26181051712020 @default.
• W2618105171 countsByYear W26181051712021 @default.
• W2618105171 countsByYear W26181051712022 @default.
• W2618105171 countsByYear W26181051712023 @default.
• W2618105171 crossrefType "journal-article" @default.
• W2618105171 hasAuthorship W2618105171A5005659473 @default.
• W2618105171 hasAuthorship W2618105171A5013643055 @default.
• W2618105171 hasAuthorship W2618105171A5015583817 @default.
• W2618105171 hasAuthorship W2618105171A5038370010 @default.
• W2618105171 hasAuthorship W2618105171A5041455638 @default.
• W2618105171 hasAuthorship W2618105171A5043310912 @default.
• W2618105171 hasAuthorship W2618105171A5063862119 @default.
• W2618105171 hasAuthorship W2618105171A5091010178 @default.
• W2618105171 hasBestOaLocation W26181051711 @default.
• W2618105171 hasConcept C104317684 @default.
• W2618105171 hasConcept C122927707 @default.
• W2618105171 hasConcept C126322002 @default.
• W2618105171 hasConcept C127561419 @default.
• W2618105171 hasConcept C134018914 @default.
• W2618105171 hasConcept C142536801 @default.
• W2618105171 hasConcept C170493617 @default.
• W2618105171 hasConcept C171089720 @default.
• W2618105171 hasConcept C185592680 @default.
• W2618105171 hasConcept C187345961 @default.
• W2618105171 hasConcept C2776175234 @default.
• W2618105171 hasConcept C2778163477 @default.
• W2618105171 hasConcept C2778913445 @default.
• W2618105171 hasConcept C55493867 @default.
• W2618105171 hasConcept C62478195 @default.
• W2618105171 hasConcept C71924100 @default.
• W2618105171 hasConcept C75217442 @default.
• W2618105171 hasConcept C86803240 @default.
• W2618105171 hasConceptScore W2618105171C104317684 @default.
• W2618105171 hasConceptScore W2618105171C122927707 @default.
• W2618105171 hasConceptScore W2618105171C126322002 @default.
• W2618105171 hasConceptScore W2618105171C127561419 @default.
• W2618105171 hasConceptScore W2618105171C134018914 @default.
• W2618105171 hasConceptScore W2618105171C142536801 @default.
• W2618105171 hasConceptScore W2618105171C170493617 @default.
• W2618105171 hasConceptScore W2618105171C171089720 @default.
• W2618105171 hasConceptScore W2618105171C185592680 @default.
• W2618105171 hasConceptScore W2618105171C187345961 @default.
• W2618105171 hasConceptScore W2618105171C2776175234 @default.
• W2618105171 hasConceptScore W2618105171C2778163477 @default.

• next