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- W2618105201 endingPage "747" @default.
- W2618105201 startingPage "747" @default.
- W2618105201 abstract "<ns4:p>The discovery and adaption of bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) systems has revolutionized the way researchers edit genomes. Engineering of catalytically inactivated Cas variants (nuclease-deficient or nuclease-deactivated [dCas]) combined with transcriptional repressors, activators, or epigenetic modifiers enable sequence-specific regulation of gene expression and chromatin state. These CRISPR–Cas-based technologies have contributed to the rapid development of disease models and functional genomics screening approaches, which can facilitate genetic target identification and drug discovery. In this short review, we will cover recent advances of CRISPR–dCas9 systems and their use for transcriptional repression and activation, epigenome editing, and engineered synthetic circuits for complex control of the mammalian genome.</ns4:p>" @default.
- W2618105201 created "2017-06-05" @default.
- W2618105201 creator A5020196665 @default.
- W2618105201 creator A5037788360 @default.
- W2618105201 date "2017-05-25" @default.
- W2618105201 modified "2023-10-04" @default.
- W2618105201 title "Genetic and epigenetic control of gene expression by CRISPR–Cas systems" @default.
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