Matches in SemOpenAlex for { <https://semopenalex.org/work/W2618179290> ?p ?o ?g. }
- W2618179290 abstract "There is evidence that development and maintenance of neural connections are disrupted in major mental disorders, which indicates that neurotrophic factors could play a critical role in their pathogenesis. Stress is a well-established risk factor for psychopathology and recent research suggests that disrupted signaling via brain-derived neurotrophic factor (BDNF) may be involved in mediating the negative effects of stress on the brain. Social isolation of rats elicits chronic stress and is widely used as an animal model of mental disorders such as schizophrenia and depression. We carried out a systematic search of published studies to review current evidence for an altered expression of BDNF in the brain of rats reared or housed in social isolation. Across all age groups (post-weaning, adolescent, adult), majority of the identified studies (16/21) reported a decreased expression of BDNF in the hippocampus. There are far less published data on BDNF expression in other brain regions. Data are also scarce to assess the behavioral changes as a function of BDNF expression, but the downregulation of BDNF seems to be associated with increased anxiety-like symptoms. The reviewed data generally support the putative involvement of BDNF in the pathogenesis of stress-related mental illness. However, the mechanisms linking chronic social isolation, BDNF expression and the elicited behavioral alterations are currently unknown." @default.
- W2618179290 created "2017-06-05" @default.
- W2618179290 creator A5010315914 @default.
- W2618179290 creator A5014058710 @default.
- W2618179290 creator A5019500602 @default.
- W2618179290 creator A5055289843 @default.
- W2618179290 date "2017-05-31" @default.
- W2618179290 modified "2023-10-16" @default.
- W2618179290 title "The Evidence for Altered BDNF Expression in the Brain of Rats Reared or Housed in Social Isolation: A Systematic Review" @default.
- W2618179290 cites W12391028 @default.
- W2618179290 cites W1490681631 @default.
- W2618179290 cites W1534639541 @default.
- W2618179290 cites W1914011667 @default.
- W2618179290 cites W1965205864 @default.
- W2618179290 cites W1967336797 @default.
- W2618179290 cites W1971606760 @default.
- W2618179290 cites W1972349566 @default.
- W2618179290 cites W1974204788 @default.
- W2618179290 cites W1975334334 @default.
- W2618179290 cites W1976481435 @default.
- W2618179290 cites W1977337541 @default.
- W2618179290 cites W1978343268 @default.
- W2618179290 cites W1979125819 @default.
- W2618179290 cites W1979978191 @default.
- W2618179290 cites W1980119453 @default.
- W2618179290 cites W1980871847 @default.
- W2618179290 cites W1984612389 @default.
- W2618179290 cites W1985803560 @default.
- W2618179290 cites W1988800128 @default.
- W2618179290 cites W1992629337 @default.
- W2618179290 cites W1993904321 @default.
- W2618179290 cites W1997944061 @default.
- W2618179290 cites W2000209446 @default.
- W2618179290 cites W2007210861 @default.
- W2618179290 cites W2007326167 @default.
- W2618179290 cites W2008620918 @default.
- W2618179290 cites W2012561426 @default.
- W2618179290 cites W2014599831 @default.
- W2618179290 cites W2019243277 @default.
- W2618179290 cites W2020644015 @default.
- W2618179290 cites W2021052829 @default.
- W2618179290 cites W2021824998 @default.
- W2618179290 cites W2036766556 @default.
- W2618179290 cites W2036846544 @default.
- W2618179290 cites W2041068600 @default.
- W2618179290 cites W2047460164 @default.
- W2618179290 cites W2049787269 @default.
- W2618179290 cites W2050069080 @default.
- W2618179290 cites W2052306601 @default.
- W2618179290 cites W2053589947 @default.
- W2618179290 cites W2058147190 @default.
- W2618179290 cites W2066577103 @default.
- W2618179290 cites W2067657652 @default.
- W2618179290 cites W2070993776 @default.
- W2618179290 cites W2072361337 @default.
- W2618179290 cites W2075642168 @default.
- W2618179290 cites W2076236287 @default.
- W2618179290 cites W2076589331 @default.
- W2618179290 cites W2077059435 @default.
- W2618179290 cites W2079965790 @default.
- W2618179290 cites W2080433636 @default.
- W2618179290 cites W2082867428 @default.
- W2618179290 cites W2082999445 @default.
- W2618179290 cites W2083534510 @default.
- W2618179290 cites W2084641178 @default.
- W2618179290 cites W2088093030 @default.
- W2618179290 cites W2089198034 @default.
- W2618179290 cites W2091194550 @default.
- W2618179290 cites W2091376817 @default.
- W2618179290 cites W2092197615 @default.
- W2618179290 cites W2093932385 @default.
- W2618179290 cites W2094544368 @default.
- W2618179290 cites W2097515789 @default.
- W2618179290 cites W2102004733 @default.
- W2618179290 cites W2109158936 @default.
- W2618179290 cites W2110157711 @default.
- W2618179290 cites W2110696099 @default.
- W2618179290 cites W2113714489 @default.
- W2618179290 cites W2115742198 @default.
- W2618179290 cites W2125681341 @default.
- W2618179290 cites W2127960611 @default.
- W2618179290 cites W2131196982 @default.
- W2618179290 cites W2133556218 @default.
- W2618179290 cites W2139565721 @default.
- W2618179290 cites W2142789104 @default.
- W2618179290 cites W2163270645 @default.
- W2618179290 cites W2171809862 @default.
- W2618179290 cites W2247777733 @default.
- W2618179290 cites W2271649262 @default.
- W2618179290 cites W2275112773 @default.
- W2618179290 cites W2291443053 @default.
- W2618179290 cites W2322761635 @default.
- W2618179290 cites W2332324138 @default.
- W2618179290 cites W2468144236 @default.
- W2618179290 cites W2497735565 @default.
- W2618179290 cites W2507208179 @default.
- W2618179290 cites W2554839660 @default.
- W2618179290 cites W2584759939 @default.
- W2618179290 cites W40040914 @default.
- W2618179290 cites W413316554 @default.