FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2618209086> ?p ?o ?g. }

• W2618209086 abstract "With the advancement of systems biology research, we have already seen great progress in pharmacology studies, especially in network pharmacology. Network pharmacology has been proven to be effective for establishing the compounds-proteins/genes-diseases network, and revealing the regulation principles of small molecules in a high-throughput manner, thus would be very effective for the analysis of drug combinations, especially for TCM preparations. In this work, we have proposed the TCM-Mesh system, which records TCM-related information collected from various resources and could serve for network pharmacology analysis for TCM preparations in a high-throughput manner (http://mesh.tcm.microbioinformatics.org/). Currently, the database contains 6,235 herbs, 383,840 compounds, 14,298 genes, 6,204 diseases, 144,723 gene-disease associations, 3,440,231 pairs of gene interactions, 163,221 side effect records and 71 toxic records, and web-based software construct a network between herbs and treated diseases, which will help to understand the underlying mechanisms for TCM preparations at molecular levels. We have used 1,293 FDA-approved drugs, as well as compounds from an herbal material Panax ginseng and a patented drug Liuwei Dihuang Wan (LDW) for evaluating our database. By comparison of different databases, as well as checking against literature, we have demonstrated the completeness, effectiveness, and accuracy of our database." @default.
• W2618209086 created "2017-06-05" @default.
• W2618209086 creator A5061373308 @default.
• W2618209086 creator A5064555151 @default.
• W2618209086 creator A5076346443 @default.
• W2618209086 creator A5086445793 @default.
• W2618209086 date "2017-06-06" @default.
• W2618209086 modified "2023-10-16" @default.
• W2618209086 title "TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations" @default.
• W2618209086 cites W138805643 @default.
• W2618209086 cites W1571757308 @default.
• W2618209086 cites W1668489970 @default.
• W2618209086 cites W1715339469 @default.
• W2618209086 cites W1970250409 @default.
• W2618209086 cites W1976146803 @default.
• W2618209086 cites W1977902851 @default.
• W2618209086 cites W1978370150 @default.
• W2618209086 cites W1980215345 @default.
• W2618209086 cites W1980961692 @default.
• W2618209086 cites W1981162405 @default.
• W2618209086 cites W1993352447 @default.
• W2618209086 cites W2010120511 @default.
• W2618209086 cites W2012730520 @default.
• W2618209086 cites W2014608611 @default.
• W2618209086 cites W2016578775 @default.
• W2618209086 cites W2017810519 @default.
• W2618209086 cites W2021448698 @default.
• W2618209086 cites W2026610180 @default.
• W2618209086 cites W2029824752 @default.
• W2618209086 cites W2036431658 @default.
• W2618209086 cites W2036621393 @default.
• W2618209086 cites W2037370850 @default.
• W2618209086 cites W2039792549 @default.
• W2618209086 cites W2041419617 @default.
• W2618209086 cites W2042952308 @default.
• W2618209086 cites W2045196111 @default.
• W2618209086 cites W2047726392 @default.
• W2618209086 cites W2048296798 @default.
• W2618209086 cites W2049515413 @default.
• W2618209086 cites W2053317726 @default.
• W2618209086 cites W2057791329 @default.
• W2618209086 cites W2068352185 @default.
• W2618209086 cites W2075160286 @default.
• W2618209086 cites W2079618522 @default.
• W2618209086 cites W2087883132 @default.
• W2618209086 cites W2094313031 @default.
• W2618209086 cites W2096173332 @default.
• W2618209086 cites W2096541451 @default.
• W2618209086 cites W2111581388 @default.
• W2618209086 cites W2113551867 @default.
• W2618209086 cites W2116036853 @default.
• W2618209086 cites W2118374937 @default.
• W2618209086 cites W2119412782 @default.
• W2618209086 cites W2119856318 @default.
• W2618209086 cites W2123500593 @default.
• W2618209086 cites W2131347449 @default.
• W2618209086 cites W2136942281 @default.
• W2618209086 cites W2137676811 @default.
• W2618209086 cites W2142572836 @default.
• W2618209086 cites W2145093771 @default.
• W2618209086 cites W2145578524 @default.
• W2618209086 cites W2146632088 @default.
• W2618209086 cites W2146907709 @default.
• W2618209086 cites W2153002689 @default.
• W2618209086 cites W2154870084 @default.
• W2618209086 cites W2159675211 @default.
• W2618209086 cites W2169678694 @default.
• W2618209086 cites W2170146596 @default.
• W2618209086 cites W2171232394 @default.
• W2618209086 cites W2171968212 @default.
• W2618209086 cites W2218148867 @default.
• W2618209086 cites W2282668969 @default.
• W2618209086 cites W2283865746 @default.
• W2618209086 cites W2316787997 @default.
• W2618209086 cites W2319887913 @default.
• W2618209086 cites W2324986020 @default.
• W2618209086 cites W2348520777 @default.
• W2618209086 cites W2364992014 @default.
• W2618209086 cites W2380875345 @default.
• W2618209086 cites W2416981882 @default.
• W2618209086 cites W2435954625 @default.
• W2618209086 cites W2472847770 @default.
• W2618209086 cites W2502230163 @default.
• W2618209086 cites W2508731920 @default.
• W2618209086 cites W2519420495 @default.
• W2618209086 cites W2552032209 @default.
• W2618209086 cites W2560738878 @default.
• W2618209086 cites W2560807741 @default.
• W2618209086 cites W4248234957 @default.
• W2618209086 cites W934783786 @default.
• W2618209086 cites W978308701 @default.
• W2618209086 doi "https://doi.org/10.1038/s41598-017-03039-7" @default.
• W2618209086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5460194" @default.
• W2618209086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28588237" @default.
• W2618209086 hasPublicationYear "2017" @default.
• W2618209086 type Work @default.
• W2618209086 sameAs 2618209086 @default.
• W2618209086 citedByCount "141" @default.
• W2618209086 countsByYear W26182090862017 @default.
• W2618209086 countsByYear W26182090862018 @default.

• next