Matches in SemOpenAlex for { <https://semopenalex.org/work/W2618367087> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2618367087 endingPage "224" @default.
- W2618367087 startingPage "224" @default.
- W2618367087 abstract "Objective: The objective of this study was to optimize the best formula for fast release suppositories of diazepam.Methods: Suppositories were prepared by fusion method using Witepsol H15 as oleaginous base, polyethylene glycol as water-soluble polymer and poloxamer 188 as water miscible base. All suppositories were evaluated for physical characteristics, in vitro drug release and kinetic models. The effects of incorporating Tween 80 as a nonionic surfactant, propylene glycol as a cosolvent, and effervescent pair on the release rate of diazepam from suppositories were investigated. Differential scanning calorimetry and Fourier transform infrared spectrometry were used to characterize physical mixtures of diazepam and the different used bases.Results: Fast release of diazepam has been obtained from suppositories containing the effervescent pair. Many formulations of diazepam have been prepared and in vitro evaluated. PEG suppositories released diazepam more efficiently than poloxamer and Witepsol suppositories. The including of an effervescent pair in the formulation of suppositories greatly enhanced the release of diazepam. The addition of Tween 80 to Witepsol suppositories, PG to poloxamer suppositories, increased the rate and extent of diazepam release.Conclusion: Fast release of diazepam has been obtained from suppositories containing the effervescent pair (formula F3), which also have good physical properties." @default.
- W2618367087 created "2017-06-05" @default.
- W2618367087 creator A5047673078 @default.
- W2618367087 creator A5074254781 @default.
- W2618367087 date "2017-09-01" @default.
- W2618367087 modified "2023-10-16" @default.
- W2618367087 title "PREPARATION AND IN VITRO EVALUATION OF FAST RELEASE DIAZEPAM SUPPOSITORIES FOR FEBRILE SEIZURES" @default.
- W2618367087 doi "https://doi.org/10.22159/ajpcr.2017.v10i9.19264" @default.
- W2618367087 hasPublicationYear "2017" @default.
- W2618367087 type Work @default.
- W2618367087 sameAs 2618367087 @default.
- W2618367087 citedByCount "1" @default.
- W2618367087 countsByYear W26183670872021 @default.
- W2618367087 crossrefType "journal-article" @default.
- W2618367087 hasAuthorship W2618367087A5047673078 @default.
- W2618367087 hasAuthorship W2618367087A5074254781 @default.
- W2618367087 hasBestOaLocation W26183670871 @default.
- W2618367087 hasConcept C101335993 @default.
- W2618367087 hasConcept C15920480 @default.
- W2618367087 hasConcept C178790620 @default.
- W2618367087 hasConcept C185592680 @default.
- W2618367087 hasConcept C2776175493 @default.
- W2618367087 hasConcept C2776964284 @default.
- W2618367087 hasConcept C2777239854 @default.
- W2618367087 hasConcept C2778042862 @default.
- W2618367087 hasConcept C43617362 @default.
- W2618367087 hasConcept C521977710 @default.
- W2618367087 hasConcept C71924100 @default.
- W2618367087 hasConcept C77281830 @default.
- W2618367087 hasConcept C98274493 @default.
- W2618367087 hasConceptScore W2618367087C101335993 @default.
- W2618367087 hasConceptScore W2618367087C15920480 @default.
- W2618367087 hasConceptScore W2618367087C178790620 @default.
- W2618367087 hasConceptScore W2618367087C185592680 @default.
- W2618367087 hasConceptScore W2618367087C2776175493 @default.
- W2618367087 hasConceptScore W2618367087C2776964284 @default.
- W2618367087 hasConceptScore W2618367087C2777239854 @default.
- W2618367087 hasConceptScore W2618367087C2778042862 @default.
- W2618367087 hasConceptScore W2618367087C43617362 @default.
- W2618367087 hasConceptScore W2618367087C521977710 @default.
- W2618367087 hasConceptScore W2618367087C71924100 @default.
- W2618367087 hasConceptScore W2618367087C77281830 @default.
- W2618367087 hasConceptScore W2618367087C98274493 @default.
- W2618367087 hasIssue "9" @default.
- W2618367087 hasLocation W26183670871 @default.
- W2618367087 hasOpenAccess W2618367087 @default.
- W2618367087 hasPrimaryLocation W26183670871 @default.
- W2618367087 hasRelatedWork W1578943998 @default.
- W2618367087 hasRelatedWork W2055150178 @default.
- W2618367087 hasRelatedWork W2061893945 @default.
- W2618367087 hasRelatedWork W2082352425 @default.
- W2618367087 hasRelatedWork W2142569149 @default.
- W2618367087 hasRelatedWork W2172172002 @default.
- W2618367087 hasRelatedWork W2618367087 @default.
- W2618367087 hasRelatedWork W4238722347 @default.
- W2618367087 hasRelatedWork W833784776 @default.
- W2618367087 hasRelatedWork W1595493767 @default.
- W2618367087 hasVolume "10" @default.
- W2618367087 isParatext "false" @default.
- W2618367087 isRetracted "false" @default.
- W2618367087 magId "2618367087" @default.
- W2618367087 workType "article" @default.