Matches in SemOpenAlex for { <https://semopenalex.org/work/W2618442076> ?p ?o ?g. }
- W2618442076 abstract "Sensitizing mutations in the epidermal growth factor receptor (EGFR) predict response to EGFR tyrosine kinase inhibitors (TKIs) and both first and second generation TKIs are available as first line treatment options in patients with advanced EGFR mutant non-small cell lung cancer (NSCLC). Eventual resistance develops with multiple mechanisms identifiable both upon repeat biopsy and in plasma circulating tumor DNA (ctDNA). The T790M gatekeeper mutation is responsible for almost 60% of cases. A number of third generation TKIs are in clinical development, and osimertinib has been approved by the FDA for the treatment of patients with EGFR T790M mutant lung cancer after failure of initial EGFR kinase therapy. Resistance mechanisms are being identified to these novel agents, and the treatment landscape of EGFR mutant lung cancer continues to evolve. The sequence of EGFR TKIs may change in the future and combination therapies targeting resistance appear highly promising." @default.
- W2618442076 created "2017-06-05" @default.
- W2618442076 creator A5017021482 @default.
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- W2618442076 date "2017-05-31" @default.
- W2618442076 modified "2023-10-11" @default.
- W2618442076 title "Third-Generation Tyrosine Kinase Inhibitors Targeting Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer" @default.
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- W2618442076 doi "https://doi.org/10.3389/fonc.2017.00113" @default.
- W2618442076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5449484" @default.
- W2618442076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28620581" @default.
- W2618442076 hasPublicationYear "2017" @default.
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