Matches in SemOpenAlex for { <https://semopenalex.org/work/W2618449050> ?p ?o ?g. }
- W2618449050 abstract "In many organisms, it remains unclear how X chromosomes are specified for dosage compensation, since DNA sequence motifs shown to be important for dosage compensation complex (DCC) recruitment are themselves not X-specific. Here, we addressed this problem in C. elegans. We found that the DCC recruiter, SDC-2, is required to maintain open chromatin at a small number of primary DCC recruitment sites, whose sequence and genomic context are X-specific. Along the X, primary recruitment sites are interspersed with secondary sites, whose function is X-dependent. A secondary site can ectopically recruit the DCC when additional recruitment sites are inserted either in tandem or at a distance (>30 kb). Deletion of a recruitment site on the X results in reduced DCC binding across several megabases surrounded by topologically associating domain (TAD) boundaries. Our work elucidates that hierarchy and long-distance cooperativity between gene-regulatory elements target a single chromosome for regulation." @default.
- W2618449050 created "2017-06-05" @default.
- W2618449050 creator A5003192242 @default.
- W2618449050 creator A5019731497 @default.
- W2618449050 creator A5042248591 @default.
- W2618449050 creator A5044211202 @default.
- W2618449050 creator A5046098376 @default.
- W2618449050 date "2017-05-30" @default.
- W2618449050 modified "2023-09-29" @default.
- W2618449050 title "Cooperation between a hierarchical set of recruitment sites targets the X chromosome for dosage compensation" @default.
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