FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2618515302> ?p ?o ?g. }

• W2618515302 abstract "The sodium-dependent citrate transporter of Klebsiella pneumoniae (KpCitS) belongs to the 2-hydroxycarboxylate transporter (2-HCT) family and allows the cell to use citrate as sole carbon and energy source in anaerobic conditions. Here we present crystal structures of KpCitS in citrate-bound outward-facing, citrate-bound asymmetric, and citrate-free inward-facing state. The structures reveal that the KpCitS dimerization domain remains stationary throughout the transport cycle due to a hydrogen bond network as well as extensive hydrophobic interactions. In contrast, its transport domain undergoes a ~35° rigid-body rotation and a ~17 Å translocation perpendicular to the membrane to expose the substrate-binding site alternately to either side of the membrane. Furthermore, homology models of two other 2-HCT proteins based on the KpCitS structure offer structural insights into their differences in substrate specificity at a molecular level. On the basis of our results and previous biochemical data, we propose that the activity of the 2-HCT CitS involves an elevator-like movement in which the transport domain itself traverses the lipid bilayer, carrying the substrate into the cell in a sodium-dependent manner." @default.
• W2618515302 created "2017-06-05" @default.
• W2618515302 creator A5015735286 @default.
• W2618515302 creator A5026612909 @default.
• W2618515302 creator A5040482204 @default.
• W2618515302 creator A5063436585 @default.
• W2618515302 creator A5074578302 @default.
• W2618515302 creator A5088628057 @default.
• W2618515302 date "2017-05-31" @default.
• W2618515302 modified "2023-10-16" @default.
• W2618515302 title "Structural insights into the elevator-like mechanism of the sodium/citrate symporter CitS" @default.
• W2618515302 cites W1529748011 @default.
• W2618515302 cites W1951534877 @default.
• W2618515302 cites W1981402419 @default.
• W2618515302 cites W1981719247 @default.
• W2618515302 cites W1981765517 @default.
• W2618515302 cites W1982521438 @default.
• W2618515302 cites W1987093495 @default.
• W2618515302 cites W1990613087 @default.
• W2618515302 cites W1997432723 @default.
• W2618515302 cites W1997459266 @default.
• W2618515302 cites W2002580946 @default.
• W2618515302 cites W2009493983 @default.
• W2618515302 cites W2009851957 @default.
• W2618515302 cites W2016562281 @default.
• W2618515302 cites W2025507554 @default.
• W2618515302 cites W2031014879 @default.
• W2618515302 cites W2034137330 @default.
• W2618515302 cites W2037562571 @default.
• W2618515302 cites W2037813720 @default.
• W2618515302 cites W2041683894 @default.
• W2618515302 cites W2041877620 @default.
• W2618515302 cites W2047913764 @default.
• W2618515302 cites W2065606015 @default.
• W2618515302 cites W2075300955 @default.
• W2618515302 cites W2075399298 @default.
• W2618515302 cites W2075560763 @default.
• W2618515302 cites W2094036652 @default.
• W2618515302 cites W2094096129 @default.
• W2618515302 cites W2095267065 @default.
• W2618515302 cites W2106541568 @default.
• W2618515302 cites W2108820109 @default.
• W2618515302 cites W2110912964 @default.
• W2618515302 cites W2111183803 @default.
• W2618515302 cites W2112135138 @default.
• W2618515302 cites W2112356541 @default.
• W2618515302 cites W2113023106 @default.
• W2618515302 cites W2116115666 @default.
• W2618515302 cites W2126241609 @default.
• W2618515302 cites W2131624523 @default.
• W2618515302 cites W2133179696 @default.
• W2618515302 cites W2149490791 @default.
• W2618515302 cites W2149906170 @default.
• W2618515302 cites W2152130162 @default.
• W2618515302 cites W2152770371 @default.
• W2618515302 cites W2155751800 @default.
• W2618515302 cites W2158266834 @default.
• W2618515302 cites W2159427026 @default.
• W2618515302 cites W2169347489 @default.
• W2618515302 cites W2188936358 @default.
• W2618515302 cites W2216424246 @default.
• W2618515302 cites W2265709850 @default.
• W2618515302 cites W2289069072 @default.
• W2618515302 cites W2320040606 @default.
• W2618515302 cites W2339377433 @default.
• W2618515302 cites W2534401341 @default.
• W2618515302 doi "https://doi.org/10.1038/s41598-017-02794-x" @default.
• W2618515302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5451387" @default.
• W2618515302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28566738" @default.
• W2618515302 hasPublicationYear "2017" @default.
• W2618515302 type Work @default.
• W2618515302 sameAs 2618515302 @default.
• W2618515302 citedByCount "13" @default.
• W2618515302 countsByYear W26185153022018 @default.
• W2618515302 countsByYear W26185153022019 @default.
• W2618515302 countsByYear W26185153022020 @default.
• W2618515302 countsByYear W26185153022021 @default.
• W2618515302 countsByYear W26185153022022 @default.
• W2618515302 crossrefType "journal-article" @default.
• W2618515302 hasAuthorship W2618515302A5015735286 @default.
• W2618515302 hasAuthorship W2618515302A5026612909 @default.
• W2618515302 hasAuthorship W2618515302A5040482204 @default.
• W2618515302 hasAuthorship W2618515302A5063436585 @default.
• W2618515302 hasAuthorship W2618515302A5074578302 @default.
• W2618515302 hasAuthorship W2618515302A5088628057 @default.
• W2618515302 hasBestOaLocation W26185153021 @default.
• W2618515302 hasConcept C104317684 @default.
• W2618515302 hasConcept C120405084 @default.
• W2618515302 hasConcept C12554922 @default.
• W2618515302 hasConcept C149011108 @default.
• W2618515302 hasConcept C185592680 @default.
• W2618515302 hasConcept C55493867 @default.
• W2618515302 hasConcept C8010536 @default.
• W2618515302 hasConcept C86803240 @default.
• W2618515302 hasConceptScore W2618515302C104317684 @default.
• W2618515302 hasConceptScore W2618515302C120405084 @default.
• W2618515302 hasConceptScore W2618515302C12554922 @default.
• W2618515302 hasConceptScore W2618515302C149011108 @default.
• W2618515302 hasConceptScore W2618515302C185592680 @default.
• W2618515302 hasConceptScore W2618515302C55493867 @default.

• next