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- W2618520281 abstract "Evidence suggested that glycogen synthase kinase-3β(GSK-3β) is involved in Nogo-66 inhibiting axonal regeneration in vitro, but its effect in vivo was poorly understood. We showed that stereotactic injection of sh RNA GSK-3β-adeno associated virus(GSK-3β-AAV) diminished syringomyelia and promoted axonal regeneration after spinal cord injury(SCI), using stereotactic injection of sh RNA GSK-3β-AAV(tested with Western blotting and RT-PCR) into the sensorimotor cortex of rats with SCI and by the detection of biotin dextran amine(BDA)-labeled axonal regeneration. We also determined the right position to inject into the sensorimotor cortex. Our findings consolidate the hypothesis that downregulation of GSK-3β promotes axonal regeneration after SCI." @default.
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- W2618520281 date "2016-01-01" @default.
- W2618520281 modified "2023-09-23" @default.
- W2618520281 title "Stereotactic Injection of shRNA GSK-3β-AAV Promotes Axonal Regeneration after Spinal Cord Injury" @default.
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