FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2618745280> ?p ?o ?g. }

• W2618745280 endingPage "127" @default.
• W2618745280 startingPage "118" @default.
• W2618745280 abstract "The mechanical properties of pulmonary tissues are important in normal function and the development of diseases such as pulmonary arterial hypertension. Hence it is critical to measure lung tissue micromechanical properties as accurately as possible in order to gain insight into the normal and pathological range of tissue stiffness associated with development, aging and disease processes. In this study, we used atomic force microscopy (AFM) micro-indentation to characterize the Young's modulus of small human pulmonary arteries (vessel diameter less than 100 µm), and examined the influence of AFM tip geometry and diameter, lung tissue section thickness and the range of working force applied to the sample on the measured modulus. We observed a significant increase of the measured Young's modulus of pulmonary vessels (one order of magnitude) associated with the use of a pyramidal sharp AFM tips (20 nm radius), compared to two larger spherical tips (1 and 2.5 µm radius) which generated statistically indistinguishable results. The effect of tissue section thickness (ranging from 10 to 50 μm) on the measured elastic modulus was relatively smaller (<1-fold), but resulted in a significant increase in measured elastic modulus for the thinnest sections (10 μm) relative to the thicker (20 and 50 μm) sections. We also found that the measured elastic modulus depends modestly (again <1-fold), but significantly, on the magnitude of force applied, but only on thick (50 μm) and not thin (10 μm) tissue sections. Taken together these results demonstrate a dominant effect of indenter shape/radius on the measured elastic modulus of pulmonary arterial tissues, with lesser effects of tissue thickness and applied force. The results of this study highlight the importance of AFM parameter selection for accurate characterization of pulmonary arterial tissue mechanical properties, and allow for comparison of literature values for lung vessel tissue mechanical properties measured by AFM across a range of indenter and indentation parameters." @default.
• W2618745280 created "2017-06-05" @default.
• W2618745280 creator A5040325695 @default.
• W2618745280 creator A5042103099 @default.
• W2618745280 creator A5050301741 @default.
• W2618745280 date "2017-10-01" @default.
• W2618745280 modified "2023-10-17" @default.
• W2618745280 title "Measured pulmonary arterial tissue stiffness is highly sensitive to AFM indenter dimensions" @default.
• W2618745280 cites W1495399017 @default.
• W2618745280 cites W1502095639 @default.
• W2618745280 cites W1519294355 @default.
• W2618745280 cites W1606715896 @default.
• W2618745280 cites W163500459 @default.
• W2618745280 cites W1827569473 @default.
• W2618745280 cites W1862989971 @default.
• W2618745280 cites W1875582044 @default.
• W2618745280 cites W1899769539 @default.
• W2618745280 cites W1913823824 @default.
• W2618745280 cites W1950871050 @default.
• W2618745280 cites W1965858639 @default.
• W2618745280 cites W1968586771 @default.
• W2618745280 cites W1969850259 @default.
• W2618745280 cites W1981966301 @default.
• W2618745280 cites W1983639828 @default.
• W2618745280 cites W1989247998 @default.
• W2618745280 cites W1997777374 @default.
• W2618745280 cites W1999445970 @default.
• W2618745280 cites W1999803321 @default.
• W2618745280 cites W2001918236 @default.
• W2618745280 cites W2012826587 @default.
• W2618745280 cites W2018006093 @default.
• W2618745280 cites W2018546430 @default.
• W2618745280 cites W2018599317 @default.
• W2618745280 cites W2023205955 @default.
• W2618745280 cites W2027052987 @default.
• W2618745280 cites W2038007769 @default.
• W2618745280 cites W2039692967 @default.
• W2618745280 cites W2041205033 @default.
• W2618745280 cites W2044428681 @default.
• W2618745280 cites W2048179019 @default.
• W2618745280 cites W2048903244 @default.
• W2618745280 cites W2062461864 @default.
• W2618745280 cites W2077857637 @default.
• W2618745280 cites W2079508597 @default.
• W2618745280 cites W2082323241 @default.
• W2618745280 cites W2085098481 @default.
• W2618745280 cites W2086707178 @default.
• W2618745280 cites W2107291281 @default.
• W2618745280 cites W2113542991 @default.
• W2618745280 cites W2124817079 @default.
• W2618745280 cites W2129314813 @default.
• W2618745280 cites W2134208433 @default.
• W2618745280 cites W2147599162 @default.
• W2618745280 cites W2155143412 @default.
• W2618745280 cites W2156897318 @default.
• W2618745280 cites W2159731793 @default.
• W2618745280 cites W2165489024 @default.
• W2618745280 cites W2166734122 @default.
• W2618745280 cites W2166739553 @default.
• W2618745280 cites W2167080502 @default.
• W2618745280 cites W2205285577 @default.
• W2618745280 cites W2308441162 @default.
• W2618745280 cites W2347862910 @default.
• W2618745280 cites W2392518456 @default.
• W2618745280 cites W2418960857 @default.
• W2618745280 cites W2420606877 @default.
• W2618745280 cites W2476542314 @default.
• W2618745280 cites W2487182228 @default.
• W2618745280 cites W2515937195 @default.
• W2618745280 cites W2543020994 @default.
• W2618745280 cites W2550838172 @default.
• W2618745280 cites W4237506791 @default.
• W2618745280 cites W4361773044 @default.
• W2618745280 doi "https://doi.org/10.1016/j.jmbbm.2017.05.039" @default.
• W2618745280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5582007" @default.
• W2618745280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28595103" @default.
• W2618745280 hasPublicationYear "2017" @default.
• W2618745280 type Work @default.
• W2618745280 sameAs 2618745280 @default.
• W2618745280 citedByCount "40" @default.
• W2618745280 countsByYear W26187452802018 @default.
• W2618745280 countsByYear W26187452802019 @default.
• W2618745280 countsByYear W26187452802020 @default.
• W2618745280 countsByYear W26187452802021 @default.
• W2618745280 countsByYear W26187452802022 @default.
• W2618745280 countsByYear W26187452802023 @default.
• W2618745280 crossrefType "journal-article" @default.
• W2618745280 hasAuthorship W2618745280A5040325695 @default.
• W2618745280 hasAuthorship W2618745280A5042103099 @default.
• W2618745280 hasAuthorship W2618745280A5050301741 @default.
• W2618745280 hasBestOaLocation W26187452802 @default.
• W2618745280 hasConcept C102951782 @default.
• W2618745280 hasConcept C121854251 @default.
• W2618745280 hasConcept C136229726 @default.
• W2618745280 hasConcept C159985019 @default.
• W2618745280 hasConcept C171250308 @default.
• W2618745280 hasConcept C178635117 @default.
• W2618745280 hasConcept C192562407 @default.

• next