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- W2618781609 abstract "Although pig represents a model species in biomedical research including studies dealing with liver patho-physiology, some aspects of liver metabolism need to be addressed. In particular, whether and how pig mitochondria can metabolize l-lactate remains to be established. We show here that pig liver mitochondria (PLM) possess their own l-lactate dehydrogenase (mL-LDH). This was shown both via immunological analysis and by assaying photometrically the L-LDH reaction in solubilised PLM. The mL-LDH reaction shows hyperbolic dependence on the substrate concentration, it is inhibited by oxamate and proves to differ from the cytosolic activity (cL-LDH), as revealed by the difference found in both pH profiles and temperature dependence of m- and cL-LDH. Titration experiments with digitonin show that mL-LDH is restricted in mitochondrial inner compartment. In agreement with the above findings, three genes in Sus scrofa genome encoded for L-LDH subunits which are predicted to have mitochondrial localization, as investigated by Target P 1.1 and PredSL analysis." @default.
- W2618781609 created "2017-06-05" @default.
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- W2618781609 date "2017-07-01" @default.
- W2618781609 modified "2023-09-25" @default.
- W2618781609 title "The occurrence of l-lactate dehydrogenase in the inner mitochondrial compartment of pig liver" @default.
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- W2618781609 doi "https://doi.org/10.1016/j.bbrc.2017.05.154" @default.
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