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- W2618796907 abstract "We report a nanosensor that uses cell lysates to rapidly profile the tumorigenicity of cancer cells. This sensing platform uses host–guest interactions between cucurbit[7]uril and the cationic headgroup of a gold nanoparticle to non-covalently modify the binding of three fluorescent proteins of a multi-channel sensor in situ. This approach doubles the number of output channels to six, providing single-well identification of cell lysates with 100% accuracy. Significantly, this classification could be extended beyond the training set, determining the invasiveness of novel cell lines. The unique fingerprint of these cell lysates required minimal sample quantity (200 ng, ∼1000 cells), making the methodology compatible with microbiopsy technology." @default.
- W2618796907 created "2017-06-05" @default.
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- W2618796907 date "2017-06-01" @default.
- W2618796907 modified "2023-10-17" @default.
- W2618796907 title "Cancer Cell Discrimination Using Host–Guest “Doubled” Arrays" @default.
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- W2618796907 doi "https://doi.org/10.1021/jacs.7b03657" @default.
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