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- W2618876465 abstract "The thermally dimorphic fungi are a unique group of fungi within the Ascomycota phylum that respond to shifts in temperature by converting between hyphae (22–25°C) and yeast (37°C). This morphologic switch, known as the phase transition, defines the biology and lifestyle of these fungi. The conversion to yeast within healthy and immunocompromised mammalian hosts is essential for virulence. In the yeast phase, the thermally dimorphic fungi upregulate genes involved with subverting host immune defenses. This review highlights the molecular mechanisms governing the phase transition and recent advances in how the phase transition promotes infection." @default.
- W2618876465 created "2017-06-05" @default.
- W2618876465 creator A5039143536 @default.
- W2618876465 date "2017-01-01" @default.
- W2618876465 modified "2023-10-13" @default.
- W2618876465 title "Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival" @default.
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- W2618876465 doi "https://doi.org/10.1155/2017/8491383" @default.
- W2618876465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5463121" @default.
- W2618876465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28626345" @default.
- W2618876465 hasPublicationYear "2017" @default.
- W2618876465 type Work @default.