Matches in SemOpenAlex for { <https://semopenalex.org/work/W2618918413> ?p ?o ?g. }
- W2618918413 abstract "The specialized structure of the neuron requires that homeostasis is sustained over the meter or more that may separate a cell body from its axonal terminus. Given this impressive distance and an axonal volume that is many times that of the cell body, how is such a compartment grown during development, re-grown after injury, and maintained throughout adulthood? While early answers to these questions focused on the local environment or the cell soma as supplying the needs of the axon, it is now well-established that the axon has some unique needs that can only be met from within. Decades of research have revealed local translation as an indispensable mechanism of axonal homeostasis during development and regeneration in both invertebrates and vertebrates. In contrast, the extent to which the adult, mammalian axonal proteome is maintained through local translation remains unclear and controversial. This mini-review aims to highlight important experiments that have helped to shape the field of axonal translation, to discuss conceptual arguments and recent evidence that supports local translation as important to the maintenance of adult axons, and to suggest experimental approaches that have the potential to further illuminate the role of axonal translation in neuronal homeostasis." @default.
- W2618918413 created "2017-06-05" @default.
- W2618918413 creator A5032743069 @default.
- W2618918413 creator A5087641165 @default.
- W2618918413 date "2017-05-31" @default.
- W2618918413 modified "2023-10-17" @default.
- W2618918413 title "Accumulating Evidence for Axonal Translation in Neuronal Homeostasis" @default.
- W2618918413 cites W1509229887 @default.
- W2618918413 cites W1522957510 @default.
- W2618918413 cites W1532048115 @default.
- W2618918413 cites W1537032494 @default.
- W2618918413 cites W1538641465 @default.
- W2618918413 cites W1555465558 @default.
- W2618918413 cites W1636792448 @default.
- W2618918413 cites W1652058896 @default.
- W2618918413 cites W1678534475 @default.
- W2618918413 cites W1964505864 @default.
- W2618918413 cites W1967397074 @default.
- W2618918413 cites W1972038062 @default.
- W2618918413 cites W1979496428 @default.
- W2618918413 cites W1986172894 @default.
- W2618918413 cites W1990413163 @default.
- W2618918413 cites W1997486888 @default.
- W2618918413 cites W2000919551 @default.
- W2618918413 cites W2005452896 @default.
- W2618918413 cites W2005456651 @default.
- W2618918413 cites W2016188701 @default.
- W2618918413 cites W2019613917 @default.
- W2618918413 cites W2024088267 @default.
- W2618918413 cites W2033382767 @default.
- W2618918413 cites W2034531378 @default.
- W2618918413 cites W2036264034 @default.
- W2618918413 cites W2037091801 @default.
- W2618918413 cites W2041675472 @default.
- W2618918413 cites W2044307053 @default.
- W2618918413 cites W2049646029 @default.
- W2618918413 cites W2050794840 @default.
- W2618918413 cites W2053137945 @default.
- W2618918413 cites W2054466443 @default.
- W2618918413 cites W2060115989 @default.
- W2618918413 cites W2064140502 @default.
- W2618918413 cites W2076038978 @default.
- W2618918413 cites W2084180648 @default.
- W2618918413 cites W2084192074 @default.
- W2618918413 cites W2085363768 @default.
- W2618918413 cites W2089977417 @default.
- W2618918413 cites W2092001080 @default.
- W2618918413 cites W2094807338 @default.
- W2618918413 cites W2102883851 @default.
- W2618918413 cites W2106410967 @default.
- W2618918413 cites W2106858079 @default.
- W2618918413 cites W2109424418 @default.
- W2618918413 cites W2111489167 @default.
- W2618918413 cites W2118218421 @default.
- W2618918413 cites W2122089332 @default.
- W2618918413 cites W2131454864 @default.
- W2618918413 cites W2133948974 @default.
- W2618918413 cites W2136333299 @default.
- W2618918413 cites W2141062015 @default.
- W2618918413 cites W2145715646 @default.
- W2618918413 cites W2146152985 @default.
- W2618918413 cites W2149121403 @default.
- W2618918413 cites W2150443013 @default.
- W2618918413 cites W2151416733 @default.
- W2618918413 cites W2161365864 @default.
- W2618918413 cites W2165775274 @default.
- W2618918413 cites W2166530541 @default.
- W2618918413 cites W2329977174 @default.
- W2618918413 cites W2440302195 @default.
- W2618918413 cites W2500444210 @default.
- W2618918413 cites W2551021318 @default.
- W2618918413 cites W2597478081 @default.
- W2618918413 cites W4231247449 @default.
- W2618918413 doi "https://doi.org/10.3389/fnins.2017.00312" @default.
- W2618918413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5450000" @default.
- W2618918413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28620277" @default.
- W2618918413 hasPublicationYear "2017" @default.
- W2618918413 type Work @default.
- W2618918413 sameAs 2618918413 @default.
- W2618918413 citedByCount "42" @default.
- W2618918413 countsByYear W26189184132018 @default.
- W2618918413 countsByYear W26189184132019 @default.
- W2618918413 countsByYear W26189184132020 @default.
- W2618918413 countsByYear W26189184132021 @default.
- W2618918413 countsByYear W26189184132022 @default.
- W2618918413 countsByYear W26189184132023 @default.
- W2618918413 crossrefType "journal-article" @default.
- W2618918413 hasAuthorship W2618918413A5032743069 @default.
- W2618918413 hasAuthorship W2618918413A5087641165 @default.
- W2618918413 hasBestOaLocation W26189184131 @default.
- W2618918413 hasConcept C104317684 @default.
- W2618918413 hasConcept C105580179 @default.
- W2618918413 hasConcept C149364088 @default.
- W2618918413 hasConcept C169760540 @default.
- W2618918413 hasConcept C171056886 @default.
- W2618918413 hasConcept C2779530196 @default.
- W2618918413 hasConcept C2779617337 @default.
- W2618918413 hasConcept C2779683492 @default.
- W2618918413 hasConcept C529278444 @default.
- W2618918413 hasConcept C55493867 @default.