Matches in SemOpenAlex for { <https://semopenalex.org/work/W2618941089> ?p ?o ?g. }
- W2618941089 endingPage "6085" @default.
- W2618941089 startingPage "6080" @default.
- W2618941089 abstract "Significance Duchenne muscular dystrophy (DMD) is a genetic X-linked neuromuscular disease characterized by severe muscle degeneration caused by absence of the protein dystrophin. In the golden retriever muscular dystrophy dog model of DMD, two atypical dogs exhibited significantly milder phenotypes compared with their severely affected littermates despite lacking dystrophin. These two notable dogs were found to have decreased expression of phosphatidylinositol transfer protein-α ( PITPNA ) compared with severely affected dogs. Decreased expression of PITPNA in dystrophin-deficient zebrafish and in human DMD myogenic cells ameliorated several aspects of the dystrophic phenotype, improving muscle structure, increasing survival, and increasing levels of phosphorylated Akt. Our findings present PITPNA as a genetic modifier of DMD and potential target for future therapies." @default.
- W2618941089 created "2017-06-05" @default.
- W2618941089 creator A5005183407 @default.
- W2618941089 creator A5006714133 @default.
- W2618941089 creator A5033216272 @default.
- W2618941089 creator A5048436189 @default.
- W2618941089 creator A5058428838 @default.
- W2618941089 creator A5061394495 @default.
- W2618941089 creator A5070788089 @default.
- W2618941089 creator A5073593526 @default.
- W2618941089 creator A5083527505 @default.
- W2618941089 creator A5087326439 @default.
- W2618941089 date "2017-05-22" @default.
- W2618941089 modified "2023-10-16" @default.
- W2618941089 title "Repression of phosphatidylinositol transfer protein α ameliorates the pathology of Duchenne muscular dystrophy" @default.
- W2618941089 cites W1530473805 @default.
- W2618941089 cites W1541007223 @default.
- W2618941089 cites W1705533001 @default.
- W2618941089 cites W1726025741 @default.
- W2618941089 cites W1739010416 @default.
- W2618941089 cites W1963549191 @default.
- W2618941089 cites W1972044172 @default.
- W2618941089 cites W1995949259 @default.
- W2618941089 cites W2006677458 @default.
- W2618941089 cites W2006865131 @default.
- W2618941089 cites W2007404892 @default.
- W2618941089 cites W2008269431 @default.
- W2618941089 cites W2013648458 @default.
- W2618941089 cites W2014257070 @default.
- W2618941089 cites W2018753432 @default.
- W2618941089 cites W2019078424 @default.
- W2618941089 cites W2038685361 @default.
- W2618941089 cites W2045493291 @default.
- W2618941089 cites W2047989785 @default.
- W2618941089 cites W2066180106 @default.
- W2618941089 cites W2081351003 @default.
- W2618941089 cites W2083321394 @default.
- W2618941089 cites W2089528462 @default.
- W2618941089 cites W2092771390 @default.
- W2618941089 cites W2096591922 @default.
- W2618941089 cites W2097739600 @default.
- W2618941089 cites W2098779810 @default.
- W2618941089 cites W2099062406 @default.
- W2618941089 cites W2111681103 @default.
- W2618941089 cites W2117889118 @default.
- W2618941089 cites W2129442835 @default.
- W2618941089 cites W2137704349 @default.
- W2618941089 cites W2145619845 @default.
- W2618941089 cites W2145822569 @default.
- W2618941089 cites W2148625376 @default.
- W2618941089 cites W2149697028 @default.
- W2618941089 cites W2150337400 @default.
- W2618941089 cites W2156590841 @default.
- W2618941089 cites W2157795344 @default.
- W2618941089 cites W2160722203 @default.
- W2618941089 cites W2161968092 @default.
- W2618941089 cites W2168829895 @default.
- W2618941089 cites W2171281605 @default.
- W2618941089 cites W2175838118 @default.
- W2618941089 cites W2209265121 @default.
- W2618941089 cites W2556789641 @default.
- W2618941089 cites W2584800155 @default.
- W2618941089 cites W4255750110 @default.
- W2618941089 cites W4294107304 @default.
- W2618941089 cites W78857381 @default.
- W2618941089 doi "https://doi.org/10.1073/pnas.1703556114" @default.
- W2618941089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5468635" @default.
- W2618941089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28533404" @default.
- W2618941089 hasPublicationYear "2017" @default.
- W2618941089 type Work @default.
- W2618941089 sameAs 2618941089 @default.
- W2618941089 citedByCount "27" @default.
- W2618941089 countsByYear W26189410892017 @default.
- W2618941089 countsByYear W26189410892018 @default.
- W2618941089 countsByYear W26189410892019 @default.
- W2618941089 countsByYear W26189410892020 @default.
- W2618941089 countsByYear W26189410892021 @default.
- W2618941089 countsByYear W26189410892022 @default.
- W2618941089 countsByYear W26189410892023 @default.
- W2618941089 crossrefType "journal-article" @default.
- W2618941089 hasAuthorship W2618941089A5005183407 @default.
- W2618941089 hasAuthorship W2618941089A5006714133 @default.
- W2618941089 hasAuthorship W2618941089A5033216272 @default.
- W2618941089 hasAuthorship W2618941089A5048436189 @default.
- W2618941089 hasAuthorship W2618941089A5058428838 @default.
- W2618941089 hasAuthorship W2618941089A5061394495 @default.
- W2618941089 hasAuthorship W2618941089A5070788089 @default.
- W2618941089 hasAuthorship W2618941089A5073593526 @default.
- W2618941089 hasAuthorship W2618941089A5083527505 @default.
- W2618941089 hasAuthorship W2618941089A5087326439 @default.
- W2618941089 hasBestOaLocation W26189410891 @default.
- W2618941089 hasConcept C104317684 @default.
- W2618941089 hasConcept C11960822 @default.
- W2618941089 hasConcept C126322002 @default.
- W2618941089 hasConcept C127716648 @default.
- W2618941089 hasConcept C134018914 @default.
- W2618941089 hasConcept C142724271 @default.
- W2618941089 hasConcept C181709278 @default.