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- W2618963767 abstract "AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA170 Background: Recently, we identified Karyopherin alpha 2 (KPNA2) expression as a tumor specific gene in esophageal cancer (BBRC 2006). KPNA2, a nuclear transport protein, is known as Importin alpha 1 or RAG cohort 1. In breast cancer, KPNA2 is a prognostic factor and plays a role in the transportation of BRCA1. However, the role of KPNA2 in esophageal cancer has not yet been reported. To evaluate the clinical significance of KPNA2 in esophageal cancer, we examined KPNA2 expression in the esophageal cancer patients. Methods: KPNA2 expression was evaluated in 86 esophageal squamous cell carcinoma patients who received esophagectomies from 1995 to 2002 by immunohistochemistry, and the results were compared with the clinicopathological findings of the subjects. Results: The patients consisted of 13 in stage1, 17 in stage2a, 20 in stage 2b, 22 in stage 3, 4 in stage 4a, and 10 in stage 4b (UICC pTNM stage). Age was 62.5(+), consisting of 67 males and 19 females. Immunohistochemical staining was done mainly in nuclei but cytoplasm was also occasionally stained. Average staining count of 5 areas of each slide ranged from 6% to 78% (average 34.3%). In 95% of the cases, more than 10% of the tumor cells were stained. In the normal esophageal epithelial cells, KPNA2 was not stained in the layer cells of the basement membrane. Then, KPNA2 expression was classified as follows: The cases with KPNA2 positive expression with less than 30% of the tumor cells (weak expression n=35) and KPNA2 positive expression of more than 30% of the tumor cells (strong expression n=51). Finally, we classified strong KPNA2 expression as KPNA2 positive. KPNA2 positivity tended to be associated with pN factor (p=0.071), however, KPNA2 expression was not associated with other clinicopathological factors of the patients. As a result, the KPNA2 positive patients tended to have a worse prognosis than that of KPNA2 negative patients (Wilcoxon p=0.373), however, multivariate analysis revealed that KPNA2 positivity was not an independent prognostic factor of the patient . Conclusion: Our results suggested that nuclear transportation is activated in esophageal cancer patients. Although 95% of esophageal cancer patients expressed KPNA2 in more than 10% of the tumor cells, KPNA2 was not a prognostic factor of the esophageal cancer patients. However, KPNA2 was not expressed in the layer cells of the basement membrane in normal epithelial cells. Thus, KPNA2 may become a new therapeutic promoter target for esophageal cancer patients." @default.
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- W2618963767 date "2008-05-01" @default.
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- W2618963767 title "Significance of Karyopherin alfa 2 (KPNA2) expression in esophageal squamous cell carcinoma" @default.
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