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- W2618982570 abstract "Abstract Organism-level systems biology in mammals aims to identify, analyze, control, and design molecular and cellular networks executing various biological functions in mammals. In particular, system-level identification and analysis of molecular and cellular networks can be accelerated by next-generation mammalian genetics. Mammalian genetics without crossing, where all production and phenotyping studies of genome-edited animals are completed within a single generation drastically reduce the time, space, and effort of conducting the systems research. Next-generation mammalian genetics is based on recent technological advancements in genome editing and developmental engineering. The process begins with introduction of double-strand breaks into genomic DNA by using site-specific endonucleases, which results in highly efficient genome editing in mammalian zygotes or embryonic stem cells. By using nuclease-mediated genome editing in zygotes, or ~100% embryonic stem cell-derived mouse technology, whole-body knock-out and knock-in mice can be produced within a single generation. These emerging technologies allow us to produce multiple knock-out or knock-in strains in high-throughput manner. In this review, we discuss the basic concepts and related technologies as well as current challenges and future opportunities for next-generation mammalian genetics in organism-level systems biology." @default.
- W2618982570 created "2017-06-05" @default.
- W2618982570 creator A5003599781 @default.
- W2618982570 creator A5021148242 @default.
- W2618982570 creator A5058747512 @default.
- W2618982570 date "2017-06-05" @default.
- W2618982570 modified "2023-10-11" @default.
- W2618982570 title "Next-generation mammalian genetics toward organism-level systems biology" @default.
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