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- W2618986821 abstract "For an intervention against the spread of communicable diseases, the idealized situation is when individuals fully comply with the intervention and the exposure to the infectious agent is comparable across all individuals. Some level of non-compliance is likely where the intervention is widely implemented. The focus is on a more accurate view of its effects population-wide. A frailty model is applied. Qualitative analysis, in mathematical terms, reveals how large variability in compliance renders the intervention less effective. This finding sharpens our vague, intuitive and empirical notions. An effective reproduction number in the presence of frailty is defined and is shown to be invariant with respect to the time-scale of disease progression. This makes the results in this paper valid for a wide spectrum of acute and chronic infectious diseases. Quantitative analysis by comparing numerical results shows that they are also robust with respect to assumptions on disease progression structure and distributions, such as with or without the latent period and the assumed distributions of latent and infectious periods." @default.
- W2618986821 created "2017-06-05" @default.
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- W2618986821 date "2017-05-01" @default.
- W2618986821 modified "2023-09-23" @default.
- W2618986821 title "A frailty model for intervention effectiveness against disease transmission
 when implemented with unobservable heterogeneity" @default.
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- W2618986821 doi "https://doi.org/10.3934/mbe.2018012" @default.
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