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- W2619034752 abstract "To study the association of the butyrylcholinesterase K variant (BChE-K) and the plasma BChE activity with mild cognitive impairment (MCI) in Thai community-dwelling patients.One hundred patients diagnosed with MCI and 100 control subjects were recruited from the community-dwelling setting in Bangkok, Thailand. The genotype and allele distributions of the BChE-K were determined by polymerase chain reaction and subsequent DNA sequencing. The BChE activity was measured in plasma according to the Ellman's method.The BChE-K allele frequencies in the Thai community-dwelling patients were in accordance with other ethnics. The BChE-K allele frequency in the control subjects (12%) was higher than that of MCI patients (5.5%), suggesting a protective role of BChE-K for MCI in the Thai community-dwelling patients. The BChE-K homozygotes were significantly associated with lower BChE activity.Our results suggested that the BChE-K may be implicated as a protective factor for MCI in the Thai community-dwelling patients, although a further study with a large sample size is warranted to confirm this." @default.
- W2619034752 created "2017-06-05" @default.
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- W2619034752 date "2017-05-01" @default.
- W2619034752 modified "2023-09-23" @default.
- W2619034752 title "Association between butyrylcholinesterase K variant and mild cognitive impairment in the Thai community-dwelling patients" @default.
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- W2619034752 doi "https://doi.org/10.2147/cia.s137264" @default.
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