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- W2619054893 abstract "Aim: Intranasal melatonin encapsulated in nanosized niosomes was preclinically evaluated. Methodology: A formula of melatonin niosomes (MN) was selected through physicochemical and cytotoxic data for pharmacokinetic, pharmacodynamics and toxicity studies in male Wistar rats. Results: Intranasal MN was bioequivalent to intravenous injection of melatonin, providing therapeutic level doses. Acute and subchronic toxicity screening showed no abnormal signs, symptoms or hematological effects in any animals. Transient nasal irritations with no inflammation were observed with intranasal MN, leading it to be categorized as relatively harmless. Conclusion: The intranasal MN could deliver melatonin to the brain to induce sleep and provide delayed systemic circulation, relative to intravenous injection and also distribute to peripheral tissue." @default.
- W2619054893 created "2017-06-05" @default.
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- W2619054893 date "2017-06-01" @default.
- W2619054893 modified "2023-10-06" @default.
- W2619054893 title "Intranasal melatonin nanoniosomes: pharmacokinetic, pharmacodynamics and toxicity studies" @default.
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- W2619054893 doi "https://doi.org/10.4155/tde-2017-0005" @default.
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